Fexaramine,574013-66-4

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Fexaramine

CAS No. : 574013-66-4

MCE 国际站：Fexaramine

产品活性：Fexaramine 是一种有效的选择性 FXR 激动剂，EC₅₀ 为 25 nM，对 hRXRα，hPPARα/γ/δ，mPXR，hPXR，hLXRα，hTRβ，hRARβ，mCAR，mERRγ 和 hVDR 受体没有活性。

研究领域：Metabolic Enzyme/Protease  |  Autophagy

作用靶点：FXR  |  Autophagy

In Vitro: Bile acid treatment is performed in HuTu-80 cells with Fexaramine (5, 25, and 50 μM) for 24 h. Fexaramine (50 μM) increases small heterodimer partner (SHP) transcript levels by 2.1-fold. The cells are treated with various concentrations of Fexaramine, and the endogenous secretin transcript levels are significantly reduced (33% in 50 μM Fexaramine). Fexaramine treatment also significantly suppresses secretin promoter activity by 32%.

In Vivo: Fexaramine treatment of DIO mice produces a striking metabolic profile that includes reduced weight gain, decreased inflammation, browning of WAT and increased insulin sensitization.

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