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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
876708-03-1
- 规格：
10 mM * 1 mL/5 mg/10 mg/25 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥1097.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥997.0 |
| 规格： | 10 mg | 产品价格： | ￥1700.0 |
| 规格： | 25 mg | 产品价格： | ￥3700.0 |
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RO-9187
CAS No. : 876708-03-1
MCE 国际站：RO-9187
产品活性：RO-9187是高效的HCV病毒复制抑制剂，IC50值为171 nM。RO-9187 是一种点击化学试剂。它含有 Azide 基团，可以和含有 Alkyne 基团的分子发生铜催化的叠氮-炔环加成反应（CuAAc)。还可以和含有 DBCO 或 BCN 基团的分子发生菌株促进的炔-叠氮环加成反应 (SPAAC)。
研究领域：Anti-infection
作用靶点：HCV
In Vitro: RO-9187 is excellent substrates for deoxycytidine kinase and is phosphorylated with efficiencies up to 3-fold higher than deoxycytidine. RO-9187 inhibits RNA synthesis by HCV polymerases from either HCV genotypes 1a and 1b or containing S96T or S282T point mutations with similar potencies, suggesting no cross-resistance with either R1479 (4′-azidocytidine) or 2′-C-methyl nucleosides. The formation of RO-9187-TP increased in a time- and dose-dependent manner. The maximal triphosphate concentration at 24 h is 87 pmol/106 cells with half-maximal triphosphate formation achieved at 12 μM RO-9187.
In Vivo: Plasma exposures of RO-9187 in rats increase in a dose-dependent manner between 10 and 2000 mg/kg after oral dosing. Plasma concentrations of 1.4 and 26 μM (390 and 7454 ng/mL) are achieved in rats and dogs at the 10 mg/kg dose level, respectively. Plasma concentrations up to 57 μM are achieved in rats dosed with 2000 mg/kg/day.
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文献和实验服务组织（ISAAA) 的生物燃料附录 （http/ / www . isaaa.org / kc/ cropbiotechupdate/ biofuels/ news/ 2007/03/09 ) 和生物燃料评述 （ http ://www . biofuelreview.eom / content/ view / 799 / 2 / ) 等网页中获取。据估计，目前全球玉米产值约有 220 亿美元，由于美国和其他一些国家对玉米的基因改良品种及生物乙醇需求的扩大，预计至 2020 年其产值可达 350
DETECTION OF RECOMBINANT PROTEINS BY ELISA
. Wait 2 hours at room temperature or overnight at 4°C. Plates coated with the 52kD Ro/SSA recombinant protein can be stored at -70°C for 2 months. The stability of other molecules may vary. Rinse the plates 5 times with PBS-Tween washing
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