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- 2025年12月05日
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- 文献和实验
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- 保存条件：
4°C, sealed storage, away from moisture
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
31828-68-9
- 规格：
10 mM * 1 mL/10 mg/25 mg/50 mg/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥264.0 |
|---|---|---|---|
| 规格： | 10 mg | 产品价格： | ￥240.0 |
| 规格： | 25 mg | 产品价格： | ￥480.0 |
| 规格： | 50 mg | 产品价格： | ￥784.0 |
| 规格： | 100 mg | 产品价格： | ￥1248.0 |
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L-Homocysteine thiolactone hydrochloride
CAS No. : 31828-68-9
MCE 国际站：L-Homocysteine thiolactone hydrochloride
产品活性：L-Homocysteine thiolactone hydrochloride是同型半胱氨酸的分子内硫酯; 防止同型半胱氨酸转化成蛋白质。
研究领域：Others
作用靶点：Others
In Vitro: In all cell types, from bacterial to human, homocysteine is metabolized to homocysteine thiolactone by methionyl-tRNA synthetase. Elevated levels of homocysteine are an independent risk factor for cardiovascular disease in humans. Homocysteine can be harmful to human cells because of its metabolic conversion to homocysteine thiolactone, a reactive thioester. This conversion occurs in all human cell types, including endothelial cells. Homocysteine thiolactone induces cell death and features of apoptosis including increased phosphotidylserine exposure on the membrane surface, increased apoptotic cells with hypoploid DNA contents, and internucleosomal DNA fragmentation in HL-60 cells. Homocysteine thiolactone is cytotoxic and capable of promoting cell death, as measured by caspase-3 activation and DNA fragmentation. HcyT strongly activates IL-8 release.
In Vivo: Homocysteine thiolactone is toxic, induces epileptic seizures in rodents, and has been implicated in Alzheimer’s disease. Homocysteine thiolactone induces two types of seizures, the coexistence of convulsive and nonconvulsive epilepsy. The grade of seizures is dose dependent.
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文献和实验S-Adenosyl-L-Homocysteine Hydrolase
The enzymatic activity that catalyzes the reversible hydrolysis of S-adenosyl-L -homocysteine (AdoHcy) to L -homocysteine (Hey) and adenosine (Ado), or, in reverse, the formation of AdoHcy from Hcy and Ado, is known as AdoHcy hydrolase (AHH
8 Determination of Plasma Homocysteine
A number of epidemiological and clinical studies have linked elevated plasma homocysteine (Hcy) to atherosclerotic vascular disease affecting coronary, carotid, and peripheral vessels. Plasma Hcy can be considered a marker of methionine
左旋茶氨酸 L-theanine 即谷酰基乙胺。是从茶叶中发现的（ Y． Saka-to， 1950）。与谷氨酸同样机制合成。
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