- ￥280 - 5200
- MedChemExpress(MCE)
- 美国
- HY-100828
- 2025年12月05日
企业认证
相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
4°C, sealed storage, away from moisture
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
66611-37-8
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg/25 mg/50 mg/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥660.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥280.0 |
| 规格： | 5 mg | 产品价格： | ￥600.0 |
| 规格： | 10 mg | 产品价格： | ￥980.0 |
| 规格： | 25 mg | 产品价格： | ￥1950.0 |
| 规格： | 50 mg | 产品价格： | ￥3200.0 |
| 规格： | 100 mg | 产品价格： | ￥5200.0 |
MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。
BGP-15
CAS No. : 66611-37-8
MCE 国际站：BGP-15
产品活性：BGP-15 是一种 PARP 抑制剂，IC50 和 Ki 值分别为 120 和 57 μM。
研究领域：Cell Cycle/DNA Damage | Epigenetics
作用靶点：PARP
In Vitro: BGP-15 (200 μM) prevents the imatinib mesylate-induced oxidative damages, attenuates the depletion of high-energy phosphates, alters the signaling effect of imatinib mesylate by preventing p38 MAP kinase and JNK activation, and induced the phosphorylation of Akt and GSK-3beta.
In Vivo: BGP-15 (15 mg/kg, p.o.) does not improve skeletal muscle pathology in older mdx mice.
In a rat model, 10 days of BGP-15 treatment greatly improves diaphragm muscle fiber function (by about 100%), although it does not reverse diaphragm atrophy. The treatment also provides protection from myosin PTMs associated with HSP72 induction and PARP-1 inhibition, resulting in improvement of mitochondrial function and content.
BGP-15 (15 mg/kg per day in saline) treatment has no effect in Ntg mice or an independent cohort of normal adult wild-type mice based on morphology, cardiac function and ECG parameters. Treatment with BGP-15 attenuates the increase in atrial size and lung weight. BGP-15 treatment is able to prevent or reduce episodes of arrhythmia. BGP-15 treatment is associated with a reduced PR interval in the HF+AF model.
BGP-15 (10 and 30 mg/kg) increases insulin sensitivity by 50% and 70%, respectively, in cholesterol-fed but not in normal rabbits. After 5 days of treatment with BGP-15, the glucose infusion rate is increased in a dose-dependent manner in genetically insulin-resistant GK rats. The most effective dose is 20 mg/kg, which shows a 71% increase in insulin sensitivity compared to control group.
相关产品：Drug Repurposing Compound Library Plus | Clinical Compound Library Plus | Bioactive Compound Library Plus | Cell Cycle/DNA Damage Compound Library | Epigenetics Compound Library | Anti-Cancer Compound Library | Clinical Compound Library | Anti-Aging Compound Library | Drug Repurposing Compound Library | Anti-diabetic Compound Library | Anti-Cardiovascular Disease Compound Library | Anti-COVID-19 Compound Library | Anti-Breast Cancer Compound Library | Anti-Pancreatic Cancer Compound Library | Rare Diseases Drug Library | Heterocyclic Compound Library | Mitochondrial Protection Compound Library | Mitochondrial Toxicity Compound Library | Highly Selective Inhibitors Library | Olaparib | XAV-939 | Talazoparib | Niraparib | Saruparib | Rucaparib | Veliparib | PJ34 | Chlorin e6 | Pamiparib | RBN-2397 | Fucosterol | Dehydrocorydaline | Fluzoparib | G007-LK | RBN012759 | 3-Aminobenzamide | AG14361 | Patritumab | Daphnetin | NVP-TNKS656 | Rucaparib monocamsylate | AZD-2461 | EB-47 dihydrochloride | Iniparib
热门产品线：重组蛋白 | 化合物库 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物
Trending products：Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Dye Reagents | PROTAC | Isotope-Labeled Compounds
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
文献和实验孔除外。 7. 温育：操作同 3 。 8. 洗涤：操作同 5 。 9. 显色：每孔先加入显色剂 A50μl ，再加入显色剂 B50μl ，轻轻震荡混匀， 37 ℃ 避光显色15 分钟. 10. 终止：每孔加终止液 50μl ，终止反应（此时蓝色立转黄色）。 11. 测定：以空白空调零， 450nm 波长依序测量各孔的吸光度（ OD 值）。 测定应在加终止
兔 骨钙素 (BGP) 酶联免疫 分析（ ELISA ） 试剂 盒使用说明书 本试剂仅供研究使用 目的：本试剂盒用于测定兔血清，血浆及相关液体样本中 骨钙素 (BGP) 的 含量。 实验原理 ： 本试剂盒应用双抗体夹心法测定 标本 中 兔 骨钙素 (BGP) 水平 。用纯化的 兔 骨钙素 (BGP) 抗体包被微孔板，制成固相抗体，往包被单抗的微孔中依次加入 骨钙素 (BGP) ，再与HRP 标记的 骨钙素 (BGP
摘 要一、人成骨肉瘤MG-63细胞株和成人成骨细胞的培养与分化特性的观察目的：观察人成骨肉瘤MG-63细胞株和正常成人成骨细胞分化的特性。方法：在细胞培养的不同时间，用α-磷酸奈酚法测定碱性磷酸酶（ALP）活性；放射免疫法测定骨钙素（BGP）含量；半定量逆转录聚合酶链反应（RT-PCR）测I型胶原、MMP-1、TIMP-1基因mRNA表达；Van GieSon氏苦味酸酸性复红染色法染色细胞I型胶原。结果：人成骨肉瘤MG-63细胞株接种培养第7天后I型胶原基因表达较高。MMP-1表达量随时间
技术资料暂无技术资料 索取技术资料
