- ￥156 - 1580
- MedChemExpress(MCE)
- 美国
- HY-100809
- 2025年12月05日
企业认证
相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 技术资料
- 保存条件：
-20°C, sealed storage, away from moisture
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
6027-91-4
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg/25 mg/50 mg/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥281.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥156.0 |
| 规格： | 5 mg | 产品价格： | ￥346.0 |
| 规格： | 10 mg | 产品价格： | ￥498.0 |
| 规格： | 25 mg | 产品价格： | ￥810.0 |
| 规格： | 50 mg | 产品价格： | ￥1130.0 |
| 规格： | 100 mg | 产品价格： | ￥1580.0 |
MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。
Guvacine hydrochloride
CAS No. : 6027-91-4
MCE 国际站：Guvacine hydrochloride
产品活性：Guvacine hydrochloride 是从槟榔中得到的生物碱，为 GABA transporter 的抑制剂，对几种克隆的 GABA 转运体具有适度的选择性，IC50 值分别为 14 μM (human GAT-1)，39 μM (rat GAT-1)，58 μM (rat GAT-2)，119 μM (human GAT-3)，378 μM (rat GAT-3) 和 1870 μM (human BGT-3)。
研究领域：Membrane Transporter/Ion Channel | Neuronal Signaling
作用靶点：GABA Receptor
In Vitro: Guvacine hydrochloride is a potent inhibitor of GABA transporter, dispalys modest selectivity forcloned GABA transporters with IC50s of 14 μM (human GAT-1), 39 μM (rat GAT-1), 58 μM (rat GAT-2), 119 μM (human GAT-3), 378 μM (rat GAT-3), and 1870 μM (human BGT-3). Guvacine has low affinity at hBGT-1 (IC50 >1 mM). Guvacine hydrochloride is a potent inhibitor of GABA uptake, but does not inhibit sodium-independent GABA binding, and is weak or inactive as a GABA receptor agonist. Guvacine inhibits the uptake GABA and β-alanine with IC50s of 23 ± 2 μM, 66 ± 11 μM in the Cat spinal cord, and 8 ± 1 μM, 123 ± 28 μM in the rat cerebral cortex, respectively.
相关产品：Natural Product Library Plus | Bioactive Compound Library Plus | Membrane Transporter/Ion Channel Compound Library | Neuronal Signaling Compound Library | Natural Product Library | Medicine Food Homology Compound Library | Neurotransmitter Receptor Compound Library | Traditional Chinese Medicine Active Compound Library | Anti-Alzheimer's Disease Compound Library | Alkaloids Library | Anti-Parkinson's Disease Compound Library | Neurodegenerative Disease-related Compound Library | Plant-Sourced Natural Product Library | GABA Receptor Compound Library | Membrane Protein-targeted Compound Library | Membrane Receptor-targeted Compound Library | Ion Channel Compound Library | Bicuculline | γ-Aminobutyric acid | Picrotoxin | Aminooxyacetic acid hemihydrochloride | Propofol | Gabazine | Riluzole | Furosemide | Baclofen | Amentoflavone | Zuranolone | CGP52432 | Vigabatrin | Flumazenil | Dihydroergotoxine mesylate | Methionine | Tiagabine hydrochloride | Etiocholanolone | L-Cycloserine | Topiramate | Jujuboside A | THIP | SKF89976A hydrochloride | Ginsenoside Rc | Basmisanil | Clomethiazole | Broflanilide | Isoguvacine hydrochloride
热门产品线：重组蛋白 | 化合物库 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物
Trending products：Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Dye Reagents | PROTAC | Isotope-Labeled Compounds
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
技术资料暂无技术资料 索取技术资料
