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- 保存条件：
-20°C, protect from light, stored under nitrogen
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
146986-50-7
- 规格：
5 mg/10 mg/50 mg/100 mg/200 mg
| 规格： | 5 mg | 产品价格： | ￥700.0 |
|---|---|---|---|
| 规格： | 10 mg | 产品价格： | ￥900.0 |
| 规格： | 50 mg | 产品价格： | ￥3200.0 |
| 规格： | 100 mg | 产品价格： | ￥5800.0 |
| 规格： | 200 mg | 产品价格： | ￥8800.0 |
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Y-27632
CAS No. : 146986-50-7
MCE 国际站：Y-27632
产品活性：Y-27632 是口服有效的，ATP 竞争性的 ROCK-I 和 ROCK-II 抑制剂，Ki 分别为 220 nM 和 300 nM。Y-27632 减弱阿霉素诱导的人心脏干细胞凋亡 (apoptosis)。Y-27632 还抑制分离诱导的小鼠前列腺干/祖细胞凋亡。Y-27632 通过上皮-间充质过渡样调节引发人诱导多能干细胞 (hIPSCs) 选择性地分化为间胚层谱系。
研究领域：Cell Cycle/DNA Damage | Stem Cell/Wnt | Cytoskeleton | TGF-beta/Smad | Apoptosis
In Vitro: Y-27632 inhibits the ROCK family of kinases 100 times more potently than other kinases including protein kinase C, cAMP-dependent kinase and myosin light chain kinase. Y-27632 prolongs the lag time and delays the appearance of BrdU-labeled cells in a concentration-dependent manner, delays of about 1 and 4 h are noticed in the Swiss 3T3 cells treated with 10 and 100 μM Y-27632, respectively.
Y-27632 promotes neuronal differentiation of adipose tissue-derived stem cells (ADSCs). Compared to 1.0 and 2.5 μM Y-27632 induced groups, percentages of neuroal-like cells achieved a peak in the 5.0 μM Y-27632 induced group.
Extracellular matrix (ECM) molecules decreases apoptosis markers and inhibiting the ROCK pathway blocks ECM stimulated actin cortical mat reformation and increases apoptosis in embryonic corneal epithelial cells.
In Vivo: Y-27632 (5 and 10 mg/kg) significantly prolongs the onset time of myoclonic jerks when compare with saline group. Y-27632 (5 and 10 mg/kg) significantly prolongs the onset time of clonic convulsions when compare with saline group. Treatment with Dimethylnitrosamine (DMN) causes a significant decrease in rat body and liver weight (DMN-S group) compared with control animals (S-S group). Oral Y27632 (30 mg/kg) essentially prevents this DMN-induced rat body and liver weight loss (DMN-Y group).
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文献和实验Preparation of Carboxypeptidase Y and Its Properties
while high efficiency habit in the scientific research. 【Requirement】 1. Use bread yeast as the original material to extract and condense carboxypeptidase Y, assay its biochemical properties. 2. Through gathering relevant published papers
用喹吖因（quinacrine）或喹吖因芥子（ quin- acrine mustard）染色，然后用荧光显微镜观察，在人的 Y染色体的长臂末端处能看到很强的荧光。在分裂期间的细胞核中也很容易看出这种荧光，因此把它叫做 Y染色质或 Y小体。由于 Y小体只有在男性中才能观察到，所以可用于人的性别鉴定。最近也已被奥林匹克运动会用于检查运动员的性别。然而这种现象只在人和大猩猩中观察到，在黑猩猩和猩猩等其他动物中， Y小体并不发出特别强的荧光。
每年到修改论文的时候，发现很多同学不懂图形和数据处理，出来的图形惨不忍睹。有的人想学没处学，有的根本不想学，最后的结果是研究生给本科生干活，老师给学生干活。所以有空的时候，想以这种方式写一点数据处理技术，给自己的未来减负。先从最简单的单X多Y图说起。 实验过程中经常遇到系列样品的表征数据，比如红外光谱、X-射线衍射等等，通常这些仪器测定的步长一致，也即X轴完全相同，这时候可以把系列数据绘制在一个图形中，图形的信息量丰富，也方便数据比较。例如这次本科论文中有一位同学的一组红外数据
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