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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years. In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
132819-92-2
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg/50 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥1130.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥800.0 |
| 规格： | 5 mg | 产品价格： | ￥1500.0 |
| 规格： | 10 mg | 产品价格： | ￥2500.0 |
| 规格： | 50 mg | 产品价格： | ￥7800.0 |
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NOD-IN-1
CAS No. : 132819-92-2
MCE 国际站：NOD-IN-1
产品活性：NOD-IN-1 是一种有效的核苷酸结合寡聚化结构域 (NOD) 样受体 NOD1 和 NOD2 的抑制剂，IC50 值分别为 5.74 μM 和 6.45 μM。
作用靶点：NOD-like Receptor (NLR)
In Vitro: NOD-IN-1 (compound 4) is potent mixed inhibitor of NOD1 and NOD2, displaying a balanced inhibitory activity on both targets in the low micromolar range. NOD-IN-1 (IC50 (NOD1)=5.74 μM; IC50 (NOD2)=6.45 μM) is identified as the best of the series, possessing NOD1- and NOD2-inhibitory activities in the lower micromolar range. These results show that NOD-IN-1 is 7-fold less potent than Noditinib-1 in terms of NOD1 inhibition and completely devoid of selective activity for NOD1 or NOD2 as opposed to Noditinib-1. NOD-IN-1 exhibits balanced dual activities of less than 10 μM on the two targets.
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文献和实验Cell-Based Reporter Assay to Analyze Activation of Nod1 and Nod2
Nod1 and Nod2 are pattern recognition receptors of the mammalian innate immune system. They respond to bacterial peptidoglycan fragments and are implicated in host defense against a variety of �different bacterial pathogens. Recent studies
通过病理学观察发现，NOD小鼠自身免疫性胰岛炎最早发生于4周龄，因而可能影响受孕率，导致早期发病小鼠不孕，发病较晚的小鼠受孕后平均初产天数、平均产仔数、平均离乳数、平均离乳率以及平均胎间隔都未受影响。对该晶系小鼠的选种，宜将离乳幼鼠均予保留，发现亲代发病，则需及时交配。 NOD小鼠发病后，充分呈现该品系小鼠糖尿病的生理生化特征即：尿频、多饮、高血糖的症状。在几周的时间内，血糖迅速升高，饮水量剧增，大量地排尿，体重迅速下降
Utilization of NOD Mice in the Study of Type 1 Diabetes
diabetic (NOD) mouse model. Investigators in Japan derived the NOD mouse line during inbreeding studies to produce a cataract-prone strain, designated CTS (1 ). This spontaneous cataract mouse model was derived from the outbred ICR mouse line
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