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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
1456632-41-9
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg/25 mg/50 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥2060.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥600.0 |
| 规格： | 5 mg | 产品价格： | ￥1500.0 |
| 规格： | 10 mg | 产品价格： | ￥2500.0 |
| 规格： | 25 mg | 产品价格： | ￥4250.0 |
| 规格： | 50 mg | 产品价格： | ￥5950.0 |
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SH5-07
CAS No. : 1456632-41-9
MCE 国际站：SH5-07
产品活性：SH5-07 是一种基于异羟肟酸的 Stat3 抑制剂，在体外实验中的 IC50 值为 3.9 μM。
研究领域：JAK/STAT Signaling | Stem Cell/Wnt
作用靶点：STAT
In Vitro: SH5-07 is a hydroxamic acid analog of BP-1-102. SH5-07 dose-dependently inhibits Stat3 activity with an IC50 of 3.9±0.6 μM in in vitro assay. It preferentially inhibits Stat3:Stat3 DNA-binding activity, ahead of inhibiting Stat1:Stat3 activity, with minimal effects on Stat1:Stat1 activity. SH5-07 binds Stat3, disrupts Stat3 association with growth factor receptor, and thereby inhibits Stat3 phosphorylation. It induces antitumor cell effects against malignant cells harboring constitutively-active Stat3. SH5-07 inhibits the expression of known Stat3-regulated genes. Bcl-2, Bcl-xL, c-Myc, Survivin, Cyclin D1 and Mcl-1 expression is reduced in response to 24 h, 5 μM SH5-07 treatment.
In Vivo: Tail vein injection or oral gavage delivery of SH5-07 or SH4-54 inhibits growth of 90-150 mm3 established subcutaneous mouse xenografts of human glioma (U251MG) and breast (MDA-MB-231) tumors that harbor aberrantly-active Stat3, associated with decreased c-Myc, Mcl-1 and Cyclin D1 expression. No significant changes in body weights, blood cell counts, or the gross anatomy of organs, or obvious signs of toxicity are observed.
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文献和实验44 4.02 3.43 3.09 2.87 2.71 2.59 2.50 2.42 2.35 2.25 2.15 2.03 1.91 1.77 1.60 44 46 4.00 3.41 3.08 2.86 2.70 2.58 2.48 2.40 2.34 2.24 2.13 2.02 1.89 1.75 1.58 46 48 3.99 3.40 3.07 2.84 2.68 2.56 2.47 2.39 2.33 2.23 2.12 2.01 1.88 1.73 1.56 48
84 45 11 75 73 88 05 90 52 27 41 14 86 22 98 12 22 08 07 52 74 95 80 33 68 05 51 18 00 33 96 02 75 19 07 60 62 93 55 59 33 82 43 90 49 37 38 44 59 34 20 46 78 73 90 97 51 40 14 02 04 02 33 31 08 39 54 16 49 36 47 95 93 13 30 35 64 19 58 97 79 15 06
5.26 5.11 5.00 4.92 4.86 4.81 9 10 10.0 7.56 6.55 5.99 5.64 5.39 5.20 5.06 4.94 4.85 4.71 4.60 4.52 4.46 4.41 10 11 9.65 7.21 6.22 5.67 5.32 5.07 4.89 4.74 4.63 4.54 4.40 4.29 4.21 4.15 4.10 11 12 9.33 6.93 5.95 5.41 5.06 4.82 4.64 4.50 4.39 4.30
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