手机验证
上海联迈生物工程有限公司
大量
LM-3903R
多克隆
Rabbit
1年
Phospho-NMDAR1 (Ser897)
磷酸化离子型谷氨酸受体1抗体
Rabbit
Human, Mouse, Rat, Chicken, Dog, Cow,
KLH conjugated Synthesised phosphopeptide derived from human NMDAR1 around the phosphorylation site of Ser897:851-938/938 <Cytoplasmic>
IgG
Lyophilized or Liquid
WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 (石蜡切片需做抗原修复)
1mg/ml
Store at -20 °C
100ul
英文名称 | Phospho-NMDAR1 (Ser897) |
中文名称 | 磷酸化离子型谷氨酸受体1抗体 |
别 名 | NMDAR1 (phospho S897); p-NMDAR1 (phospho S897); NMDA-NR1; N-Methyl-d-Asprtate receptor 1; GRIN1; NMDA1; NR1; Glutamate [NMDA] receptor subunit zeta 1; Glutamate receptor ionotropic N methyl D aspartate 1; Grin 1; Grin1; N methyl D aspartate receptor channel; N-methyl-D-aspartate receptor; N-methyl-D-aspartate receptor subunit NR1; NMD-R1; NMDA 1; NMDA NR1; NMDA R1; NMDA receptor 1; NMDA1; NMDAR 1; NMDAR; NR 1; NMDZ1_HUMAN. |
规格价格 | 100ul/1580元 购买 大包装/询价 |
说 明 书 | 100ul |
产品类型 | 磷酸化抗体 |
研究领域 | 细胞生物 免疫学 神经生物学 信号转导 转录调节因子 激酶和磷酸酶 细胞膜受体 细胞类型标志物 |
抗体来源 | Rabbit |
克隆类型 | Polyclonal |
交叉反应 | Human, Mouse, Rat, Chicken, Dog, Cow, |
产品应用 | WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 (石蜡切片需做抗原修复) not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
分 子 量 | 103kDa |
细胞定位 | 细胞膜 |
性 状 | Lyophilized or Liquid |
浓 度 | 1mg/ml |
免 疫 原 | KLH conjugated Synthesised phosphopeptide derived from human NMDAR1 around the phosphorylation site of Ser897:851-938/938 <Cytoplasmic> |
亚 型 | IgG |
纯化方法 | affinity purified by Protein A |
储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
PubMed | PubMed |
产品介绍 | background: The protein encoded by this gene is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and learning. Cell-specific factors are thought to control expression of different isoforms, possibly contributing to the functional diversity of the subunits. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008] Function: NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. This protein plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors. Subunit: Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B); disulfide-linked. Found in a complex with GRIN2A or GRIN2B, GRIN3A or GRIN3B and PPP2CB. Interacts with DLG4 and MPDZ (By similarity). Interacts with LRFN1 and LRFN2 (By similarity). Interacts with MYZAP. Subcellular Location: Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Post-translational modifications: NMDA is probably regulated by C-terminal phosphorylation of an isoform of NR1 by PKC. Dephosphorylated on Ser-897 probably by protein phosphatase 2A (PPP2CB). Its phosphorylated state is influenced by the formation of the NMDAR-PPP2CB complex and the NMDAR channel activity. DISEASE: Defects in GRIN1 are the cause of mental retardation autosomal dominant type 8 (MRD8) [MIM:614254]. Mental retardation is characterized by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Similarity: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR1/GRIN1 subfamily. SWISS: Q05586 Gene ID: 2902 Database links: Entrez Gene: 2902 Human Entrez Gene: 14810 Mouse Entrez Gene: 24408 Rat Omim: 138249 Human SwissProt: Q05586 Human SwissProt: P35438 Mouse SwissProt: P35439 Rat Unigene: 558334 Human Unigene: 278672 Mouse Unigene: 9840 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 神经细胞标志物 (NMDAR1)N-甲基-D-天门冬氨酸受体(NMDAR)是兴奋性氨基酸受体亚型之一,是由NMDAR1与不同的NMDAR2亚基组成的异聚体。 NMDAR1又称GluR1 (Glutamate Receptor 1)近年实验研究发现,许多NMDAR拮抗药均具有镇痛活性,表明NMDAR在痛觉传递中具有重要作用,这为新型镇痛药的研究开发提供了新的作用靶点。 |
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