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- Roche
- 罗氏 11376497001
- 2025年11月26日
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- 文献和实验
- 技术资料
- 保质期：
见产品外包装
- 英文名：
Insulin, human
- 库存：
需确认
- 供应商：
嵘崴达
- CAS号：
11061-68-0
- 保存条件：
2-8度
- 规格：
100mg
Insulin, human
recombinant (yeast)
General description
Recombinant Insulin, human, is produced in yeast and purified by standard chromatographic techniques. Insulin regulates blood glucose. In muscles and adipocytes it stimulates glucose intake and metabolism. It also controls the expression and various enzymes.
Specificity
Insulin, human, is active on most mammalian cells.
Application
Insulin shows a broad range of activities on a variety of somatic cells. Recombinant human insulin can be used to stimulate growth and proliferation of cultured cells and to investigate insulin activity on sensitive cells used in research studies. It is also a component of serum-free media formulations for most primary cells and cell lines.
Biochem/physiol Actions
由胰岛β-细胞所产生的二链多肽激素。其分子量为~5800 Da。α链和β链是由两个链间二硫键所连接的。α链含有一个链间二硫键。胰岛素可调节细胞对葡萄糖、氨基酸和脂肪酸的摄取、利用和储存，并抑制糖原、蛋白质和脂肪的分解。
| 10814407001 | Peroxidase (POD), EIA Grade, 1 | 100 mg |
| 11333151001 | Mouse IgG ELISA | 1 kit (400 tests) |
| 11663925910 | Mycoplasma PCR ELISA 1pc | 1 kit (96 reactions) |
| 4744926001 | Cytotoxicity Det.Kit PLUS (LDH | 1 kit (400 tests in 96 wells) |
| 11054589001 | Endoproteinase Asp-N Seq. Grad | 3 x 2 µg |
| 11699709001 | ATP Bioluminescence Assay Kit | 1 kit [1,000 assays (microplate), 500 assays (tube)] |
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文献和实验Analysis of Insulin and Insulin-Like Growth Factor-I Receptors in Neural Tissues
A variety of biochemical and physiological studies in recent years have made it clear that the brain possesses specific receptors and puta- tive signal transduction pathways for insulin and the insulin-like growth factors (IGF-I and IGF
Assaying Tyrosine Phosphorylation of Insulin Receptor and Insulin Receptor Substrates
This chapter describes techniques to successfully detect tyrosine phosphorylation of the insulin receptor and insulin receptor substrate proteins. These assays demonstrate whether the insulin signaling pathway is activated at its earliest
的第 6与第 11位氨基酸之间也有一个二硫键。 人胰岛素分子量为 5734道尔顿，等电点为 pH5.6。在酸性环境（ pH2.5～ 3.5）较稳定，在碱性溶液中易被破坏，可形成锌、钴等胰岛素结晶。又由于其分子中酸性氨基酸较多，可与碱性蛋白如鱼精蛋白等结合，形成分子量大、溶解量低的鱼精蛋白锌胰岛素。此种制剂注入皮下或肌肉吸收较慢，作用时间长，为长效胰岛素。从胰岛分泌的胰岛素，经门脉进入肝脏， 40～ 50％在肝内分解，其余进入体循环分布于全身。从静脉注射胰岛素， 90％在 20分钟内从血液中消失
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