脂多糖 来源于大肠杆菌 0111:B4

脂多糖 来源于大肠杆菌 0111:B4

γ-irradiated, BioXtra, suitable for cell culture

别名:
LPS

一般描述

Lipopolysaccharides (LPS) are intricate molecules consisting of lipids and polysaccharides, predominantly present in the outer membrane of Gram-negative bacteria. Comprising lipid A, the core oligosaccharide (core), and the O-specific polysaccharide or O antigen (OAg), LPS is anchored to the outer bacterial membrane, with lipid A primarily responsible for its associated toxicity. Functioning as a potent activator of the proinflammatory response, LPS engages various mammalian cells, including macrophages, monocytes, and endothelial cells. While serving a protective role for Gram-negative bacteria against environmental stress, LPS also triggers recognition by the innate immune system during infections.

应用

该LPS血清型已用于刺激B细胞并在人肝细胞中诱导NOS。
脂多糖（LPS）是革兰氏阴性菌细胞壁的特征组分。LPS及其脂质A部分可通过能够识别常见的病原体相关分子模式（PAMP）的Toll样受体蛋白家族成员Toll样受体4（TLR4）刺激先天性免疫系统细胞。

生化/生理作用

脂多糖是绝大多数革兰氏阴性菌细胞壁的一种主要组成成分。它是一种高免疫原性抗原，具有增强针对可溶性抗原免疫应答的能力。LPS还可作为来自小鼠、兔、鸡、牛、仓鼠和人骨髓来源的B淋巴细胞的一种特异性促分裂原。

特点和优势

• High-purity compound suitable for a wide variety of research applications

重悬

脂多糖以经γ-射线处理的冻干粉形式提供。如需重悬，可将1 ml无菌的平衡盐溶液或组织培养基加入至小瓶（1 mg）中并轻轻晃动直至粉末溶解。重悬后的产品可采用无菌的平衡盐溶液或组织培养基进一步被稀释至所需的工作浓度。