- ¥1380 - 2200
- 康朗生物
- kl-5791R
- 中国/美国/德国
- 2026年03月26日
- WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 Flow-Cyt=1μg/Test IF=1:100-500
- Rabbit
- Human, Mouse, Rat,
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- 详细信息
- 文献和实验
- 技术资料
- 供应商：
上海康朗生物科技有限公司
- 库存：
大量
- 目录编号：
kl-5791R
- 克隆性：
多克隆
- 抗原来源：
Rabbit
- 保质期：
12个月
- 抗体英文名：
Integrin Alpha V + Beta 6 antibody
- 抗体名：
整合素αVβ6抗体
- 宿主：
Rabbit
- 适应物种：
Human, Mouse, Rat,
- 免疫原：
KLH conjugated synthetic peptide derived from human Integrin Alpha V + Beta 6:
- 亚型：
IgG
- 形态：
冻干粉或液体
- 应用范围：
WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 Flow-Cyt=1μg/Test IF=1:100-500
- 浓度：
1mg/ml
- 保存条件：
-20 °C
- 规格：
100ul 200ul
| 中文名称 | 整合素αVβ6抗体 |
| 别 名 | CD51; Integrin alpha-V light chain; integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51); Integrin, alpha V; Integrin, beta 6; ITAV_HUMAN; ITGAV; ITGB6; Vitronectin receptor subunit alpha. |
 |
Specific References (2) | bs-5791R has been referenced in 2 publications. [IF=8.31] Gao, Duo, et al."A near-infrared phthalocyanine dye-labeled agent for integrin avb6-targeted theranostics of pancreatic cancer." Biomaterials 53 (2015):229-238. IHC-P ; Human. PubMed:25890722 [IF=3.02] Li, Haixia, et al. "Scutellarin inhibits the growth and invasion of human tongue squamous carcinoma through the inhibition of matrix metalloproteinase-2 and-9 and αvβ6 integrin." International Journal of Oncology 42.5 (2013): 1674-1681. IHC-P ; Mouse. PubMed:23546449 |
| 规格价格 | 100ul/1380元 购买 200ul/2200元 购买 大包装/询价 |
| 说 明 书 | 100ul 200ul |
| 研究领域 | 肿瘤 心血管 细胞生物 免疫学 信号转导 生长因子和激素 细胞粘附分子 细胞骨架 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, |
| 产品应用 | WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 Flow-Cyt=1μg/Test IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 18/95/113kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Integrin Alpha V + Beta 6: |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| PubMed | PubMed |
| 产品介绍 | background: Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. Aberrant integrin expression has been found in many epithelial tumours. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells. Integrin alpha-v beta-6 is upregulated in cancers and during tissue remodelling but is absent from resting adult tissues. Integrin alpha-v beta-6 promotes invasion and correlates with poor survival and therefore makes a promising therapeutic target. Function: The alpha-V integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. Subunit: Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-V associates with either beta-1, beta-3, beta-5, beta-6 or beta-8 subunit. Interacts with HIV-1 Tat. Alpha-V/beta-6 binds to foot-and-mouth disease virus (FMDV) VP1 protein and acts as a receptor for this virus (By similarity). Alpha-V/beta-6 binds to coxsackievirus A9 and coxsackievirus B1 capsid proteins and acts as a receptor for these viruses. Interacts with RAB25. Subcellular Location: Membrane; Single-pass type I membrane protein. Similarity: Belongs to the integrin alpha chain family. Contains 7 FG-GAP repeats. SWISS: P06756 Gene ID: 3685 Database links: Entrez Gene: 3685 Human Omim: 193210 Human SwissProt: P06756 Human Unigene: 436873 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 产品图片 |  Sample:Cerebrum (Rat) Lysate at 40 ug Primary: Anti-Integrin Alpha V+Beta 6(bs-5791R)at 1/300 dilution Secondary: IRDye800CW Goat Anti-RabbitIgG at 1/20000 dilution Predicted band size: 18/95/113kD Observed band size: 113kD  Sample:Siha Cell (Human) Lysate at 40 ug Primary: Anti-Integrin Alpha V + Beta 6(bs-5791R)at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 18/95/113 kD Observed band size: 95 kD  Sample: Kidney (Mouse) Lysate at 40 ug Primary: Anti-Integrin Alpha V + Beta 6 (bs-5791R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 18/95/113 kD Observed band size: 95 kD  Blank control(blue): Hela (fixed with 2% paraformaldehyde (10 min) , then permeabilized with 90% ice-cold methanol for 30 min on ice). Primary Antibody:Rabbit Anti-Integrin Alpha V + Beta 6 antibody(bs-5791R), Dilution:1μg in 100 μL 1X PBS containing 0.5% BSA; Isotype Control Antibody: Rabbit IgG(orange) ,used under the same conditions ); Secondary Antibody: Goat anti-rabbit IgG-PE(white blue), Dilution: 1:200 in 1 X PBS containing 0.5% BSA. |
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, C., Chung, A. E., and McDonald, J. A. (1995) A novel role for alpha 3 beta 1integrins in extracellular matrix assembly. J. Cell Sci. 108, 2511–2523. 9. Lotz, M. M., Burdsal, C. A., Erickson, H. P., and McClay, D. R. (1989) Celladhesion
β亚单位，除α7和αIEL外，其它粘合素分子亚单位均已基因克隆成功。α亚单位和β亚单位组合构成粘合素分子并不是随机的，多数α亚单位只能与一种β亚单位结合构成异源双体，但也有的α亚单位可与几种不同的β亚单位组合，如αV（CD51）可分别同β1、β3、β5、β6和β8亚单位组成integrin分子，而大部分β单位则可以结合数种不同
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