手机验证
上海联迈生物工程有限公司
大量
LM-1290R
多克隆
Rabbit
1年
CCN1
富半胱氨酸肝素结合蛋白61抗体
Rabbit
Human, Mouse, Rat, Dog, Cow, Horse, Sheep,
KLH conjugated synthetic peptide derived from human Cyr61:251-379/379
IgG
Lyophilized or Liquid
WB=1:500-2000 ELISA=1:500-1000 IHC-F=1:400-800 IF=1:100-500 (石蜡切片需做抗原修复)
1mg/ml
Store at -20 °C
50ul 100ul 200ul
英文名称 | CCN1 |
中文名称 | 富半胱氨酸肝素结合蛋白61抗体 |
别 名 | Cyr61; IGFBP10; cysteine rich protein 61; 3CH61; CCN 1; CCN1; CYR 61; CYR61; CYR61 protein; CYR61 protein precursor; Cysteine rich angiogenic inducer 61; Cysteine rich heparin binding protein 61; GIG 1; GIG1; GIG1; Igfbp 10; IGFBP10; Insulin like growth factor binding protein 10; Protein CYR61; Protein GIG1; AI325051; cysteine rich 61; CYR61_HUMAN . |
规格价格 | 50ul/780元 购买 100ul/1380元 购买 200ul/2200元 购买 大包装/询价 |
说 明 书 | 50ul 100ul 200ul |
研究领域 | 肿瘤 |
抗体来源 | Rabbit |
克隆类型 | Polyclonal |
交叉反应 | Human, Mouse, Rat, Dog, Cow, Horse, Sheep, |
产品应用 | WB=1:500-2000 ELISA=1:500-1000 IHC-F=1:400-800 IF=1:100-500 (石蜡切片需做抗原修复) not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
分 子 量 | 42kDa |
细胞定位 | 分泌型蛋白 |
性 状 | Lyophilized or Liquid |
浓 度 | 1mg/ml |
免 疫 原 | KLH conjugated synthetic peptide derived from human Cyr61:251-379/379 |
亚 型 | IgG |
纯化方法 | affinity purified by Protein A |
储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
PubMed | PubMed |
产品介绍 | background: The secreted protein encoded by this gene is growth factor-inducible and promotes the adhesion of endothelial cells. The encoded protein interacts with several integrins and with heparan sulfate proteoglycan. This protein also plays a role in cell proliferation, differentiation, angiogenesis, apoptosis, and extracellular matrix formation. [provided by RefSeq, Sep 2011] Function: Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up-regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5. CYR61-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3. Subcellular Location: Secreted. Similarity: Belongs to the CCN family. Contains 1 CTCK (C-terminal cystine knot-like) domain. Contains 1 IGFBP N-terminal domain. Contains 1 TSP type-1 domain. Contains 1 VWFC domain. SWISS: O00622 Gene ID: 3491 Database links: Entrez Gene: 3491 Human Entrez Gene: 16007 Mouse Entrez Gene: 83476 Rat Entrez Gene: 508941 Cow Omim: 602369 Human SwissProt: O00622 Human SwissProt: P18406 Mouse SwissProt: Q9ES72 Rat Unigene: 8867 Human Unigene: 1231 Mouse Unigene: 22129 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 高半胱氨酸蛋白61是富含半胱氨酸的分泌性肝素连接蛋白,是CCN家族成员之一,属于生长因子诱导的即刻早期基因,有明显的促有丝分裂和趋化活性作用,有诱导成纤维细胞增殖和分泌细胞外基质等功能,可促进细胞增殖、迁移、黏附、分化和细胞外基质(ECM)合成的作用,在新生血管及肿瘤形成过程中起着重要作用。 |
产品图片 | Sample: U251 Cell Lysate at 40 ug Primary: Anti-CCN1 (bs-1290R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 42 kD Observed band size: 48 kD |
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