Specific References (1) | bs-3155R has been referenced in 1 publications. [IF=5.58] Lehman, Stacey L., Sandra Ryeom, and Constantinos Koumenis. "Signaling through alternative Integrated Stress Response pathways compensates for GCN2 loss in a mouse model of soft tissue sarcoma." Scientific Reports 5 (2015). WB ; Mouse. PubMed:26123823
规格价格
100ul/1580元 购买 大包装/询价
说 明 书
100ul
产品类型
磷酸化抗体
研究领域
肿瘤 细胞生物 染色质和核信号 神经生物学 信号转导 激酶和磷酸酶
抗体来源
Rabbit
克隆类型
Polyclonal
交叉反应
Human, Mouse, Rat, Dog, Cow, Horse,
产品应用
WB=1:500-2000 ELISA=1:500-1000 Flow-Cyt=1ug/Test (石蜡切片需做抗原修复) not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分 子 量
189kDa
细胞定位
细胞浆
性 状
Lyophilized or Liquid
浓 度
1mg/ml
免 疫 原
KLH conjugated Synthesised phosphopeptide derived from human GCN2 around the phosphorylation site of Thr899:HL(p-T)GM
亚 型
IgG
纯化方法
affinity purified by Protein A
储 存 液
0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件
Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed
PubMed
产品介绍
background: GCN2 belongs to a family of kinases that phosphorylate the alpha subunit of eukaryotic translation initiation factor 2 to downregulate protein synthesis in response to varied cellular stresses.
Function: Can phosphorylate the alpha subunit of EIF2 and may mediate translational control.
Tissue Specificity: Widely expressed.
Post-translational modifications: Autophosphorylated on threonine residues.
Similarity: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily. Contains 2 protein kinase domains. Contains 1 RWD domain.
SWISS: Q9P2K8
Gene ID: 440275
Database links:
Entrez Gene: 440275 Human
Entrez Gene: 27103 Mouse
Entrez Gene: 114859 Rat
Omim: 609280 Human
SwissProt: Q9P2K8 Human
SwissProt: Q9QZ05 Mouse
Unigene: 656673 Human
Unigene: 217616 Mouse
Unigene: 8333 Rat
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.