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上海康朗生物科技有限公司
大量
kl-2216R
多克隆
Rabbit
12个月
IL-1RA antibody
白介素-1受体拮抗剂抗体
Rabbit
Human, Mouse, Rat, Dog, Pig, Cow, Sheep,
KLH conjugated synthetic peptide derived from human IL-1RA:26-120/178
IgG
冻干粉或液体
WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500
1mg/ml
-20 °C
100ul 200ul
中文名称 | 白介素-1受体拮抗剂抗体 |
别 名 | Interleukin-1 receptor antagonist; ICIL 1RA; IL1 inhibitor; ICIL1RA; IL1F3; IL1RN; IRAP; IL1RA_HUMAN. |
规格价格 | 100ul/1380元 购买 200ul/2200元 购买 大包装/询价 |
说 明 书 | 100ul 200ul |
研究领域 | 免疫学 |
抗体来源 | Rabbit |
克隆类型 | Polyclonal |
交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Sheep, |
产品应用 | WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 (石蜡切片需做抗原修复) not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
分 子 量 | 17kDa |
细胞定位 | 细胞浆 分泌型蛋白 |
性 状 | Lyophilized or Liquid |
浓 度 | 1mg/ml |
免 疫 原 | KLH conjugated synthetic peptide derived from human IL-1RA:26-120/178 |
亚 型 | IgG |
纯化方法 | affinity purified by Protein A |
储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
PubMed | PubMed |
产品介绍 | background: IL1RA is a member of the Interleukin 1 cytokine family. This protein inhibits the activities of Interleukin 1, alpha (IL1A) and Interleukin 1, beta (IL1B), and modulates a variety of Interleukin 1 related immune and inflammatory responses. This gene and five other closely related cytokine genes form a gene cluster spanning approximately 400 kb on chromosome 2. A polymorphism of this gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. Function: Inhibits the activity of interleukin-1 by binding to eceptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity. Binds functional interleukin-1 receptor IL1R1 with greater affinity than decoy receptor IL1R2; however, the physiological relevance of the latter association is unsure. Subcellular Location: Isoform 1: Secreted. Isoform 2, 3, 4: Cytoplasm. Tissue Specificity: The intracellular form of IL1RN is predominantly expressed in epithelial cells. DISEASE: Microvascular complications of diabetes 4 (MVCD4) [MIM:612628]: Pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. Interleukin 1 receptor antagonist deficiency (DIRA) [MIM:612852]: A rare autoinflammatory disease of skin and bone resulting in sterile multifocal osteomyelitis, periostitis, and pustulosis from birth. The term autoinflammatory disease describes a group of disorders characterized by attacks of seemingly unprovoked inflammation without significant levels of autoantibodies and autoreactive T-cells. Note=The disease is caused by mutations affecting the gene represented in this entry. SWISS: P25085 Gene ID: 3557 Database links: Entrez Gene: 3557 Human Entrez Gene: 16181 Mouse Entrez Gene: 60582 Rat Omim: 147679 Human SwissProt: P18510 Human SwissProt: P25085 Mouse SwissProt: P25086 Rat Unigene: 81134 Human Unigene: 882 Mouse Unigene: 162640 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. IL-1受体拮抗剂(IL-1ra)是IL-1强有力的内生拮抗剂,通过与白细胞介素-1的Ⅰ型和Ⅱ型受体结合,特异性地阻断白细胞介素-1的生物学作用。白介素1受体拮抗剂(IL-1Ra)是体内天然的一种对IL-1有拮抗作用的细胞因子。 |
产品图片 | Sample: Lane1:Plasma(Mouse) Tissue Lysate at 30 ug Lane2:Hemocyte(Mouse) Tissue Lysate at 30 ug Primary: Anti-IL-1RA (bs-2216R)at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 18 kD Observed band size: 23 kD Sample: Spleen(Mouse) Tissue Lysate at 30 ug Primary: Anti-IL-1RA (bs-2216R)at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 18 kD Observed band size: 23 kD Tissue/cell: Human oral squamous cell carcinoma; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-IL-1RA Polyclonal Antibody, Unconjugated(bs-2216R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining |
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