WB=1:500-2000 ELISA=1:500-1000 (石蜡切片需做抗原修复) not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分 子 量
30/47kDa
细胞定位
分泌型蛋白
性 状
Lyophilized or Liquid
浓 度
1mg/ml
免 疫 原
KLH conjugated synthetic peptide derived from human TGF-beta 3:321-412/412
Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed
PubMed
产品介绍
background: The TGFBeta superfamily is composed of numerous growth and differentiation factors, including transforming growth factors Beta(TGFBeta) 1,2 and 3; placental transforming growth factor (PTGFBeta);growth /differentiation factors (GDFs); mullerian inhibiting substance (MIS);bone morphogenic proteins (BMPs);glial cell line-derived neurotrophic factor (GDNF);inhibins or activins (Alpha,Beta-A, Beta-B and Beta-C),Lefty and Nodal. Members of the TGF superfamily are involved in embryonic development and adult tissue homeostasis.
Function: Involved in embryogenesis and cell differentiation.
Subunit: Homodimer; disulfide-linked. Interacts with ASPN.
Subcellular Location: Secreted.
DISEASE: Defects in TGFB3 are a cause of familial arrhythmogenic right ventricular dysplasia type 1 (ARVD1) [MIM:107970]; also known as arrhythmogenic right ventricular cardiomyopathy 1 (ARVC1). ARVD is an autosomal dominant disease characterized by partial degeneration of the myocardium of the right ventricle, electrical instability, and sudden death. It is clinically defined by electrocardiographic and angiographic criteria; pathologic findings, replacement of ventricular myocardium with fatty and fibrous elements, preferentially involve the right ventricular free wall.
Similarity: Belongs to the TGF-beta family.
SWISS: P10600
Gene ID: 7043
Database links:
Entrez Gene: 7043 Human
Entrez Gene: 21809 Mouse
Entrez Gene: 25717 Rat
Omim: 190230 Human
SwissProt: P10600 Human
SwissProt: P17125 Mouse
SwissProt: Q07258 Rat
Unigene: 592317 Human
Unigene: 3992 Mouse
Unigene: 7018 Rat
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
生长因子和激素( Growth Factor and Hormones) TGF是一种多效生长因子,对上皮细胞增值有潜在抑制作用,可抑制肿瘤生长,用于许多恶性肿瘤如:胃癌、肺癌、膀胱癌、肾癌、前列腺癌、结肠癌等多种恶性肿瘤的研究。分子量:47kDa。此抗体是TGFβ3 特异性抗体,与TGF-β1和TGF-β2没有交叉反应。
产品图片
Sample:Ovary (Mouse)Lysate at 40 ug Primary: Anti-TGF-beta 3(bs-20413R)at 1/300 dilution Secondary: IRDye800CW Goat Anti-RabbitIgG at 1/20000 dilution Predicted band size: 30'47kD Observed band size: 47kD