- ¥780 - 2200
- LMAI Bio
- LM-0227R
- 进口/国产
- 2025年07月15日
- WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 Flow-Cyt=1μg/Test ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
- Rabbit
- Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,
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- 详细信息
- 文献和实验
- 技术资料
- 供应商：
上海联迈生物工程有限公司
- 库存：
大量
- 目录编号：
LM-0227R
- 克隆性：
多克隆
- 抗原来源：
Rabbit
- 保质期：
1年
- 抗体英文名：
IGF1R
- 抗体名：
胰岛素样生长因子I受体抗体
- 宿主：
Rabbit
- 适应物种：
Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,
- 免疫原：
KLH conjugated synthetic peptide derived from human IGF-1R alpha chain:251-350/1367
- 亚型：
IgG
- 形态：
Lyophilized or Liquid
- 应用范围：
WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 Flow-Cyt=1μg/Test ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
- 浓度：
1mg/ml
- 保存条件：
Store at -20 °C
- 规格：
50ul 100ul 200ul
| 英文名称 | IGF1R |
| 中文名称 | 胰岛素样生长因子I受体抗体 |
| 别 名 | CD221; CD221 antigen; IGF1 Receptor; IGF 1 receptor; IGF 1R; IGF I receptor; IGF1R; IGFIR; IGFIRC; Insulin like growth factor 1 receptor; Insulin like growth factor 1 receptor precursor; JTK13; MGC142170; MGC142172; IGF1R_HUMAN; Insulin-like growth factor 1 receptor beta chain; IGF 1 receptor; IGF-1R; IGF I receptor; IGF-I receptor; IGF-IR. |
 |
Specific References (3) | bs-0227R has been referenced in 3 publications. [IF=2.38] Yang, Shaobo, et al. "Insulin-Like Growth Factor-1 Modulates Polycomb Cbx8 Expression and Inhibits Colon Cancer Cell Apoptosis." Cell Biochemistry and Biophysics (2014): 1-5. WB ; Human. PubMed:25398592 [IF=1.21] Müller, L., et al. "Different expression of leptin and IGF1 in the adult and prepubertal testis in dogs." Reproduction in Domestic Animals (2017). IHC-P ; Dog. PubMed:0 [IF=2.19] Hu, Wei, et al. "MicroRNA let-7a and let-7f as novel regulatory factors of the sika deer (Cervus nippon) IGF-1R gene." Growth Factors 0 (2013): 1-7. WB ; PubMed:24294913 |
| 规格价格 | 50ul/780元 购买 100ul/1380元 购买 200ul/2200元 购买 大包装/询价 |
| 说 明 书 | 50ul 100ul 200ul |
| 研究领域 | 肿瘤 免疫学 信号转导 生长因子和激素 转录调节因子 激酶和磷酸酶 细胞膜受体 糖尿病 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, |
| 产品应用 | WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 Flow-Cyt=1μg/Test ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 78/150kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human IGF-1R alpha chain:251-350/1367 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| PubMed | PubMed |
| 产品介绍 | background: This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. [provided by RefSeq, Jul 2008]. Function: This receptor binds insulin-like growth factor 1 (IGF1) with a high affinity and IGF2 with a lower affinity. It has a tyrosine-protein kinase activity, which is necessary for the activation of the IGF1-stimulated downstream signaling cascade. When present in a hybrid receptor with INSR, binds IGF1. PubMed:12138094 shows that hybrid receptors composed of IGF1R and INSR isoform Long are activated with a high affinity by IGF1, with low affinity by IGF2 and not significantly activated by insulin, and that hybrid receptors composed of IGF1R and INSR isoform Short are activated by IGF1, IGF2 and insulin. In contrast, PubMed:16831875 shows that hybrid receptors composed of IGF1R and INSR isoform Long and hybrid receptors composed of IGF1R and INSR isoform Short have similar binding characteristics, both bind IGF1 and have a low affinity for insulin. Subunit: Tetramer of 2 alpha and 2 beta chains linked by disulfide bonds. The alpha chains contribute to the formation of the ligand-binding domain, while the beta chain carries the kinase domain. Interacts with PIK3R1 and with the PTB/PID domains of IRS1 and SHC1 in vitro when autophosphorylated on tyrosine residues. Forms a hybrid receptor with INSR, the hybrid is a tetramer consisting of 1 alpha chain and 1 beta chain of INSR and 1 alpha chain and 1 beta chain of IGF1R. Interacts with ARRB1 and ARRB2. Subcellular Location: Membrane; Single-pass type I membrane protein. Tissue Specificity: Found as a hybrid receptor with INSR in muscle, heart, kidney, adipose tissue, skeletal muscle, hepatoma, fibrobasts, spleen and placenta (at protein level). Expressed in a variety of tissues. Post-translational modifications: The cytoplasmic domain of the beta subunit is autophosphorylated on tyrosine residues in response to insulin-like growth factor I (IGF I). Phosphorylation of Tyr-980 is required for IRS1- and SHC1-binding. DISEASE: Defects in IGF1R may be a cause in some cases of resistance to insulin-like growth factor 1 (IGF1 resistance) [MIM:270450]. IGF1 resistance is a gowth deficiency disorder characterized by intrauterine growth retardation and poor postnatal growth accompanied with increased plasma IGF1. Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. Contains 3 fibronectin type-III domains. Contains 1 protein kinase domain. SWISS: P08069 Gene ID: 3480 Database links: Entrez Gene: 3480 Human Entrez Gene: 16001 Mouse Entrez Gene: 25718 Rat Omim: 147370 Human SwissProt: P08069 Human SwissProt: Q60751 Mouse SwissProt: P24062 Rat Unigene: 643120 Human Unigene: 714012 Human Unigene: 275742 Mouse Unigene: 10957 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 产品图片 |   Positive control: (mo)Splenocytes(2% Paraformaldehyde-fixed ) Isotype Control Antibody Antibody: Rabbit IgG; Supplier: Cell Signaling Technology; Dilution: 1μg in 100 μl 1 X PBS containing 0.5% BSA Secondary Antibody Antibody: Goat anti-rabbit IgG-FITC; Supplier: Cell Signaling Technology; Dilution: 1:200 in 1 X PBS containing 0.5% BSA Primary Antibody Supplier: Bioss; Supplier catalog number: bs-0227R; Dilution: 1μg in 100 μl 1X PBS containing 0.5% BSA |
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文献和实验症综合征的遗传热点。由于WAPCre系统，这种点突变只在小鼠的乳腺中活跃，通过这种突变，该菌株将在1岁左右自发地发展出与人类相关的乳腺肿瘤。我们经常让这些小鼠模型接触胰岛素样分子。频繁注射两种模型化合物AspB10和胰岛素样生长因子-1（IGF1）后，大鼠乳腺肿瘤的表达明显降低。AspB10，又称X10，是一种早期胰岛素类似物，由于增强了IGF1R结合亲和力，具有很强的启动细胞分裂的潜力。IGF1是IGF1R的天然配体，这种受体在细胞分裂信号中起着重要作用。与常规胰岛素相比，甘精胰岛素在体外实验中
的点突变而得名;一种与人类李弗罗梅尼癌症综合征基因热点相对应的基因。由于WAPCre系统，该位点突变只在小鼠乳腺中活跃，在1岁左右，该菌株会自发地发展为人类相关乳腺肿瘤。我们经常将这些小鼠模型暴露在类胰岛素分子中。频繁注射两种模型化合物AspB10和胰岛素样生长因子-1 (IGF1)后，肿瘤表达明显下降，这两种模型化合物均与大鼠乳腺肿瘤相关。AspB10，也被称为X10，是一种早期的胰岛素类似物，由于增强了IGF1R的结合亲和力，具有启动细胞分裂的强大潜力。IGF1是IGF1R的天然配体，该受体在细胞
的物理性嗅觉干预即可显著抑制同侧嗅球中肿瘤的发生与发展。综上，利用化学遗传学以及物理方法，研究团队充分证明了嗅觉感知可以调控胶质瘤的发生。 利用硅胶塞剥夺小鼠嗅觉可以抑制嗅球中胶质瘤 接下来，研究团队对嗅觉调控胶质瘤发生的分子机制进行了探究。 通过对单侧嗅觉剥夺小鼠的两侧嗅球组织进行转录组测序，筛选出了潜在效应因子- 胰岛素样生长因子 1（IGF1）。 有趣的是，团队之前发表的工作已经证明了前癌细胞表达的 IGF1 受体（IGF1R）对胶质瘤发生发展具有重要作用，支持对 IGF
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