Human WISP-3 Recombinant Prote

Recombinant Human WISP-3

产品描述

WISP-3 is a member of the CCN family of secreted cysteine rich regulatory proteins. It is predominantly expressed in the adult kidney, testis, and fetal kidney, but it is also found with weaker expression in the placenta, ovary, prostate, small intestine, and skeletally-derived cells. WISP-3 is required for normal postnatal skeletal growth and cartilage homeostasis. Recombinant Human WISP-3 is a 36.8 kDa protein containing 331 amino acid residues. It is composed of four distinct structural domains (modules): the IGF binding protein (IGFBP) domain, the von Willebrand Factor C (VWFC) domain, the thrombospondin type-1 repeat (TSP type-1) domain, and a C-terminal cysteine knot-like (CTCK) domain.

Source:E.coli

Synonyms:WNT-1 inducible signaling pathway protein-3, CCN6

Purity:≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity:The ED₅₀ was determined by the dose-dependant proliferation of the MCF-7 cell line. The expected ED₅₀ for this effect is 0.2-0.3 µg/ml.


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