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上海康朗生物科技有限公司
大量
kl-1144R
多克隆
Rabbit
12个月
TFPI-2 antibody
组织因子途径抑制剂-2抗体
Rabbit
Human, Mouse, Rat, Cow,
KLH conjugated synthetic peptide derived from human TFPI2:135-235/235
IgG
冻干粉或液体
ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500
1mg/ml
-20 °C
100ul 200ul
中文名称 | 组织因子途径抑制剂-2抗体 |
别 名 | tissue factor pathway inhibitor 2; TFPI-2; TFPI2; TFPI2_HUMAN; Tissue factor pathway inhibitor 2; Placental protein 5; PP5; TFPI 2; TFPI 2; TFPI2 PEN. |
Specific References (1) | bs-1144R has been referenced in 1 publications. [IF=0.34] Wang, Gui-Jun, et al. "Expression of tissue factor pathway inhibitor-2 in gastric stromal tumor and its clinical significance." Experimental and Therapeutic Medicine. IHC-P ; Human. PubMed:24396436 |
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规格价格 | 100ul/1380元 购买 200ul/2200元 购买 大包装/询价 |
说 明 书 | 100ul 200ul |
研究领域 | 心血管 细胞生物 |
抗体来源 | Rabbit |
克隆类型 | Polyclonal |
交叉反应 | Human, Mouse, Rat, Cow, |
产品应用 | ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 (石蜡切片需做抗原修复) not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
分 子 量 | 25kDa |
细胞定位 | 分泌型蛋白 |
性 状 | Lyophilized or Liquid |
浓 度 | 1mg/ml |
免 疫 原 | KLH conjugated synthetic peptide derived from human TFPI2:135-235/235 |
亚 型 | IgG |
纯化方法 | affinity purified by Protein A |
储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
PubMed | PubMed |
产品介绍 | background: TFPI2 may play a role in the regulation of plasmin-mediated matrix remodeling. It inhibits trypsin, plasmin, factor VIIa/tissue factor and weakly factor Xa, but it has no effect on thrombin. TFPI2 is specific to umbilical vein endothelial cells, liver, placenta, heart, pancreas, and maternal serum at advanced pregnancy. This inhibitor contains three inhibitory domains. TFPI2 contains 3 BPTI/Kunitz inhibitor domains. Function: May play a role in the regulation of plasmin-mediated matrix remodeling. Inhibits trypsin, plasmin, factor VIIa/tissue factor and weakly factor Xa. Has no effect on thrombin. Subcellular Location: Secreted (constituent of proteinaceous extracellular matrix) Tissue Specificity: Umbilical vein endothelial cells, liver, placenta, heart, pancreas, and maternal serum at advanced pregnancy. Similarity: Contains 3 BPTI/Kunitz inhibitor domains. SWISS: P48307 Gene ID: 7980 Database links: Entrez Gene: 7980 Human Omim: 600033 Human SwissProt: P48307 Human Unigene: 438231 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 组织因子途径抑制因子(tissue factor pathway in hibitor, TFPI)是组织因子凝血途径的主要抑制因子, 组织因子途径抑制因子在诸如动脉粥样硬化,血管再狭窄,弥漫性血管内凝血DIC等方面,有一定的研究价值。 TFPI-2也称为胎盘蛋白-5(placenta protein 5,PP5)或细胞基质联合丝氨酸蛋白酶抑制物(matrix associated serine protease inhibitor,MSPI)。 TFPI-2是相对分子质量为:25KDa的丝氨酸蛋白酶抑制物, 由脉管系统细胞(内皮细胞、平滑肌细胞、成纤维细胞)合成,并沉积在这些细胞的细胞外基质里。TFPI-2为广谱丝氨酸蛋白酶抑制剂,能有效地抑制基质金属蛋白酶(MMP)、纤溶酶、胰蛋白酶、糜蛋白酶、组织蛋白酶等多种蛋白水解酶的活性,在维持细胞外基质(ECM)结构完整、抑制肿瘤细胞浸润转移方面起着重要作用。TFPI-2分布广泛,在人肝脏、肾脏、心脏、骨骼肌等正常组织中有着高度表达,而在肿瘤组织中也有一定程度的表达。 |
产品图片 | Paraformaldehyde-fixed, paraffin embedded (Rat heart); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (TFPI-2) Polyclonal Antibody, Unconjugated (bs-1144R) at 1:400 overnight at 4°C, followed by a conjugated secondary antibody (sp-0023) for 20 minutes and DAB staining. Tissue/cell: human placenta tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-TFPI-2 Polyclonal Antibody, Unconjugated(bs-1144R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining |
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