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上海康朗生物科技有限公司
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kl-11399R
多克隆
Rabbit
12个月
Synaptotagmin XI antibody
突触结合蛋白11抗体
Rabbit
Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,
KLH conjugated synthetic peptide derived from human Synaptotagmin XI (51-100aa):51-100/431
IgG
冻干粉或液体
ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500
1mg/ml
-20 °C
100ul 200ul
中文名称 | 突触结合蛋白11抗体 |
别 名 | Synaptotagmin 11; Synaptotagmin 12; Synaptotagmin XI; Synaptotagmin-11; synaptotagmin XII; synaptotagmin-XII; Synaptotagmin11; Synaptotagmin12; Synaptotagmin-11; Synaptotagmin-12; SynaptotagminXI; SYT 11; SYT 12; SYT-11; SYT-12; Syt XI; Syt11; SYT11_HUMAN; SYT12; SytXI; DKFZp781D015; KIAA0080; MGC10881; MGC17226. |
规格价格 | 100ul/1380元 购买 200ul/2200元 购买 大包装/询价 |
说 明 书 | 100ul 200ul |
研究领域 | 细胞生物 神经生物学 信号转导 |
抗体来源 | Rabbit |
克隆类型 | Polyclonal |
交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, |
产品应用 | ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复) not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
分 子 量 | 48kDa |
细胞定位 | 细胞浆 细胞膜 |
性 状 | Lyophilized or Liquid |
浓 度 | 1mg/ml |
免 疫 原 | KLH conjugated synthetic peptide derived from human Synaptotagmin XI (51-100aa):51-100/431 |
亚 型 | IgG |
纯化方法 | affinity purified by Protein A |
储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
PubMed | PubMed |
产品介绍 | background: Synaptotagmins are a large family of synaptic vesicle type III integral membrane proteins that function as regulators of both exocytosis and endocytosis and are involved in neurotransmitter secretion from small secretory vesicles. Synaptotagmin XI, also known as SYT11 (Synaptotagmin-11), is a 431 amino acid protein that localizes to the membrane and is expressed ubiquitously with highest expression in brain and lung. Like other Synaptotagmin proteins, Synaptotagmin XI is involved in the calcium-dependent exocytosis of secretory vesicles and is thought to act as a calcium sensor during vesicular trafficking. Synaptotagmin XI contains two C2 domains through which it can bind either three calcium ions or the zinc-finger protein Parkin (a juvenile Parkinson’s disease gene product), the latter of which causes the polyubiquitination and subsequent degradation of Synaptotagmin XI by the proteasome complex. Defects in the gene encoding Synaptotagmin XI are implicated in a number of neurological disorders, including schizophrenia and Parkinson’s disease. Function: May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Subunit: Homodimer. Can also form heterodimers. Interacts with PARK2. Subcellular Location: Membrane; Single-pass membrane protein. Cell junction, synapse. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass membrane protein. Note=In substantia nigra, observed in neuronal cell bodies and neurites. Found in the core of the Lewy bodies in the brain of sporadic Parkinson disease patients. Post-translational modifications: Ubiquitinated and targeted to the proteasome complex for degradation. Similarity: Belongs to the synaptotagmin family. Contains 2 C2 domains. SWISS: Q9BT88 Gene ID: 23208 Database links: Entrez Gene: 23208 Human Entrez Gene: 229521 Mouse Entrez Gene: 60568 Rat Omim: 608741 Human SwissProt: Q9BT88 Human SwissProt: Q9R0N3 Mouse SwissProt: O08835 Rat Unigene: 32984 Human Unigene: 379376 Mouse Unigene: 9805 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
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