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上海康朗生物科技有限公司
大量
kl-11288R
多克隆
Rabbit
12个月
GBP2 antibody
G蛋白结合蛋白2抗体
Rabbit
Human, Mouse, Rat, Sheep,
KLH conjugated synthetic peptide derived from human GBP2:401-500/591
IgG
冻干粉或液体
ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500
1mg/ml
-20 °C
100ul 200ul
中文名称 | G蛋白结合蛋白2抗体 |
别 名 | GBP 2; GBP2; GBP-2; GTP binding protein 2; Guanine nucleotide binding protein 2; Guanylate binding protein 2 interferon inducible; HuGBP 2; HuGBP2; GBP2_HUMAN. |
Specific References (1) | bs-11288R has been referenced in 1 publications. [IF=3.12] Mori, Gentaro, et al. "The genes Scgb1a1, Lpo and Gbp2 characteristically expressed in peri‐implant epithelium of rats." Clinical Oral Implants Research (2015). IHC-P ; Rat. PubMed:25864924 |
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规格价格 | 100ul/1380元 购买 200ul/2200元 购买 大包装/询价 |
说 明 书 | 100ul 200ul |
研究领域 | 免疫学 信号转导 结合蛋白 G蛋白信号 |
抗体来源 | Rabbit |
克隆类型 | Polyclonal |
交叉反应 | Human, Mouse, Rat, Sheep, |
产品应用 | ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复) not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
分 子 量 | 67kDa |
细胞定位 | 细胞核 细胞浆 细胞膜 |
性 状 | Lyophilized or Liquid |
浓 度 | 1mg/ml |
免 疫 原 | KLH conjugated synthetic peptide derived from human GBP2:401-500/591 |
亚 型 | IgG |
纯化方法 | affinity purified by Protein A |
储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
PubMed | PubMed |
产品介绍 | background: Guanylate-binding proteins, GBP1 and GBP2 are GTP-binding proteins with a high-turnover GTPase activity and an antiviral effect (1-4). GBP1 mediates an antiviral effect against vesicular stomatitis virus and encephalomyocarditis virus and plays a role in the IFN-mediated antiviral response against these viruses (4). GBP1 and GBP2 belong to a group of large GTP-binding proteins with a high concentration-dependent GTPase activity that have the common ability to undergo oligomerization (1). GBP1 and GBP2 are bone marrow-derived GTPases encoded by interferon-activated genes and are inducible following IFN treatment (2,3). Specifically, GBP1 is expressed in cultured mammary epithelial tumor cell lines after treatment with IFN-gamma and LPS (5). Function: Guanylate-binding proteins (GBPs) are characterized by their ability to specifically bind guanine nucleotides (GMP, GDP, and GTP). GBP2 is a GTPase that converts GTP to GDP and GMP. Subunit: Homodimerizes upon GTP-binding, dimerization is required for the second hydrolysis step from GDP to GMP. Can also heterodimerize with other members of the family. Subcellular Location: Cytoplasm. Nucleus. Golgi apparatus membrane; Lipid-anchor. Similarity: Belongs to the GBP family. SWISS: P32456 Gene ID: 2634 Database links: Entrez Gene: 2634 Human Entrez Gene: 14469 Mouse Entrez Gene: 171164 Rat Omim: 600412 Human SwissProt: P32456 Human SwissProt: Q9Z0E6 Mouse SwissProt: Q63663 Rat Unigene: 386567 Human Unigene: 24038 Mouse Unigene: 25736 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
产品图片 | Paraformaldehyde-fixed, paraffin embedded (Rat brain); Antigen retrieval by microwave in sodium citrate buffer (pH6.0) ; Block endogenous peroxidase by 3% hydrogen peroxide for 30 minutes; Blocking buffer (3% BSA) at RT for 30min; Antibody incubation with (GBP2) Polyclonal Antibody, Unconjugated (bs-11288R) at 1:400 overnight at 4℃, followed by conjugation to the secondary antibody (labeled with HRP)and DAB staining. |
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