BMY-25271,78441-82-4

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BMY-25271

CAS No. : 78441-82-4

MCE 国际站：BMY-25271

产品活性：BMY-25271 是一个组胺 H2 受体 (histamine H2 receptor) 拮抗剂。

研究领域：GPCR/G Protein  |  Neuronal Signaling  |  Immunology/Inflammation

作用靶点：Histamine Receptor

In Vivo: BMY-25271 is a histamine H2 receptor antagonist. The dose response curves are parallel and oral ED₅₀ values derived from probit analysis are 0.093, 0.97 and 6.9 mg/kg for BMY-25271, ranitidine and cimetidine, respectively. BMY-25271, therefore, is about 10 and 74 times more potent than ranitidine and cimetidine, respectively. Pretreatment with the highest dose of BMY-25271 does not significantly affect the absorption of aspirin or the formation of its major metabolite, salicylic acid.

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