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- 2025年12月04日
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1039825-68-7
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询盘
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MCH-1 antagonist 1
CAS No. : 1039825-68-7
MCE 国际站：MCH-1 antagonist 1
产品活性：MCH-1 antagonist 1 是一种有效的黑色素浓缩激素 1 (MCH-1) 拮抗剂，Ki 值为 2.6 nM。MCH-1 antagonist 1 还抑制 CYP3A4，IC50 为 10 μM。
研究领域：GPCR/G Protein | Neuronal Signaling | Metabolic Enzyme/Protease
作用靶点：MCHR1 (GPR24) | Cytochrome P450
In Vitro: MCH-1 antagonist 1 (Compound 1) also inhibits cytochrome P450 3A4 (CYP3A4) with an IC50 of 10 μM.
In Vivo: MCH-1 antagonist 1 is administered to male C57BL/6J DIO mice to assess their pharmacokinetic profile. Effect of MCH-1 antagonist 1 (dosed at 30 mg/kg, po) is measured on the body weight of DIO mice with the AUC0-6 h of 14760 h*ng/mL.
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文献和实验末梢血红细胞参数和网织红细胞计数对新生儿缺铁性贫血的临床指导
、63例、70例和68例。其中以RDW 阳性率93.3%为最高，Ret阳性率90.7%次之；而在非IDA组RDW也有26.7%的阳性率，Ret则仅有3.3%的阳性率。IDA组各项参数阳性率显著高于非IDA组。结果见表1 表1 两组不同原因贫血病例红细胞参数与网织红细胞计数结果 组别nMCV阳性率%MCH阳性率%MCHC阳性率%RDW阳性率%Ret阳性率% IDA组7566(88.0)62(82.7)63(84.0)70(93.3)68(90.7) 非IDA组605(8.3)8(13
MCH pg 23.25-26.03 369 MCHC
[3H](+)MK801 Radioligand Binding Assay at the N‐Methyl‐D‐Aspartate Receptor
for agonist and antagonist compounds. (A ) These curves show the anticipated profile of a glycine site agonist added alone (open symbols) or in the presence (filled symbols) of the glycine site antagonist, 5,7‐dichlorokynurenate (5 µM). Data are modeled based
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