- ¥780 - 2200
- 康朗生物
- kl-1011R
- 中国/美国/德国
- 2025年07月13日
- WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 Flow-Cyt=1μg/Test IF=1:100-500
- Rabbit
- Human, Mouse, Rat, Cow, Rabbit,
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- 详细信息
- 文献和实验
- 技术资料
- 供应商：
上海康朗生物科技有限公司
- 库存：
大量
- 目录编号：
kl-1011R
- 克隆性：
多克隆
- 抗原来源：
Rabbit
- 保质期：
12个月
- 抗体英文名：
CXCR4 antibody
- 抗体名：
细胞表面趋化因子受体4抗体
- 宿主：
Rabbit
- 适应物种：
Human, Mouse, Rat, Cow, Rabbit,
- 免疫原：
KLH conjugated synthetic peptide derived from the middle of human CD184 (211-254aa):201-294/352 <Extracellular>
- 亚型：
IgG
- 形态：
冻干粉或液体
- 应用范围：
WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 Flow-Cyt=1μg/Test IF=1:100-500
- 浓度：
1mg/ml
- 保存条件：
-20 °C
- 规格：
50ul 100ul 200ul
CXCR4 antibody
| 中文名称 | 细胞表面趋化因子受体4抗体 |
| 别 名 | C-X-C chemokine receptor type 4; CXC-R4; CXCR-4; Stromal cell-derived factor 1 receptor; SDF-1 receptor; Fusin; Leukocyte-derived seven transmembrane domain receptor; LESTR; CD184 antigen; CXCR4_HUMAN. |
 |
Specific References (9) | bs-1011R has been referenced in 9 publications. [IF=8.98] Pei, Guangchang, et al. "Renal Interstitial Infiltration and Tertiary Lymphoid Organ Neogenesis in IgA Nephropathy." Clinical Journal of the American Society of Nephrology (2013): CJN-01150113. IHC-P ; Human. PubMed:24262509 [IF=7.84] Zhuo, Wei, et al. ʺThe CXCL12–CXCR4 Chemokine Pathway: A Novel Axis Regulates Lymphangiogenesis.ʺ Clinical Cancer Research 18.19 (2012): 5387-5398. Human, Mouse. PubMed:22932666 [IF=0.68] Lu Z, Qi L, Bo XJ, Liu GD, Wang JM, Li G. Expression of CD26 and CXCR4 in prostate carcinoma and its relationship with clinical parameters. CD26 and CXCR4 expression shows correlation with prostate cancer. J Res Med Sci 2013;18:647-52 Human. PubMed:24379839 [IF=3.33] Wu, Qiang, et al. "B-cell lymphoma 6 protein stimulates oncogenicity of human breast cancer cells." BMC Cancer 14.1 (2014): 418. WB ; Human. PubMed:24917186 [IF=2.86] Mori, Miki, et al. "Stromal Cell-Derived Factor-1α Plays a Crucial Role Based on Neuroprotective Role in Neonatal Brain Injury in Rats." International Journal of Molecular Sciences 16.8 (2015): 18018-18032. IHC-F ; Rat. PubMed:26251894 [IF=3.26] Mu, Hailong, et al. "PLZF‐Induced Upregulation of CXCR4 Promotes Dairy Goat Male Germline Stem Cell Proliferation by Targeting Mir146a." Journal of Cellular Biochemistry (2015). WB ; Goat. PubMed:26365432 [IF=1.43] Wang, Xiao-yan, et al. "AMD3100 attenuates MMP-3 and MMP-9 expressions and prevents cartilage degradation in a monosodium iodoacetate-induced rat model of temporomandibular osteoarthritis." Journal of Oral and Maxillofacial Surgery (2016). IHC-P ; Rat. PubMed:26851314 [IF=4.26] Aerbajinai, Wulin, et al. "Glia Maturation Factor-γ Regulates Monocyte Migration through Modulation of β1-Integrin." Journal of Biological Chemistry291.16 (2016): 8549-8564. WB, FCM ; Human. PubMed:26895964 [IF=3.30] Ochi, Akinobu, et al. "MIF-2/D-DT Enhances Proximal Tubular Cell Regeneration Through SLPI and ATF4-dependent Mechanisms." American Journal of Physiology-Renal Physiology (2017). WB ; Mouse. PubMed:28539339 |
| 规格价格 | 50ul/780元 购买 100ul/1380元 购买 200ul/2200元 购买 大包装/询价 |
| 说 明 书 | 50ul 100ul 200ul |
| 研究领域 | 肿瘤 免疫学 细胞膜受体 细胞类型标志物 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Cow, Rabbit, |
| 产品应用 | WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 Flow-Cyt=1μg/Test IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 40kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from the middle of human CD184 (211-254aa):201-294/352 <Extracellular> |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| PubMed | PubMed |
| 产品介绍 | background: This gene encodes a CXC chemokine receptor specific for stromal cell-derived factor-1. The protein has 7 transmembrane regions and is located on the cell surface. It acts with the CD4 protein to support HIV entry into cells and is also highly expressed in breast cancer cells. Mutations in this gene have been associated with WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. Monomer. Can form dimers. Function: Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 X4 isolates and as a primary receptor for some HIV-2 isolates. Promotes Env-mediated fusion of the virus. Subunit: Monomer. Can form dimmers. Subcellular Location: Cell membrane; Multi-pass membrane protein. Tissue Specificity: Expressed in numerous tissues, such as peripheral blood leukocytes, spleen, thymus, spinal cord, heart, placenta, lung, liver, skeletal muscle, kidney, pancreas, cerebellum, cerebral cortex and medulla (in microglia as well as in astrocytes), brain microvascular, coronary artery and umbilical cord endothelial cells. Isoform 1 is predominant in all tissues tested. Post-translational modifications: Phosphorylated on agonist stimulation. Rapidly phosphorylated on serine and threonine residues in the C-terminal. Phosphorylation at Ser-324 and Ser-325 leads to recruitment of ITCH, ubiquitination and protein degradation. Ubiquitinated by ITCH at the cell membrane on agonist stimulation. The ubiquitin-dependent mechanism, endosomal sorting complex required for transport (ESCRT), then targets CXCR4 for lysosomal degradation. This process is dependent also on prior Ser-/Thr-phosphorylation in the C-terminal of CXCR4. Also binding of ARRB1 to STAM negatively regulates CXCR4 sorting to lysosomes though modulating ubiquitination of SFR5S. Sulfation on Tyr-21 is required for efficient binding of CXCL12/SDF-1alpha and promotes its dimerization. O- and N-glycosylated. Asn-11 is the principal site of N-glycosylation. There appears to be very little or no glycosylation on Asn-176. N-glycosylation masks coreceptor function in both X4 and R5 laboratory-adapted and primary HIV-1 strains through inhibiting interaction with their Env glycoproteins. The O-glycosylation chondroitin sulfate attachment does not affect interaction with CXCL12/SDF-1alpha nor its coreceptor activity. DISEASE: Defects in CXCR4 are a cause of WHIM syndrome (WHIM) [MIM:193670]; also known as warts, hypogammaglobulinemia, infections and myelokathexis. WHIM syndrome is an immunodeficiency disease characterized by neutropenia, hypogammaglobulinemia and extensive human papillomavirus (HPV) infection. Despite the peripheral neutropenia, bone marrow aspirates from affected individuals contain abundant mature myeloid cells, a condition termed myelokathexis. Similarity: Belongs to the G-protein coupled receptor 1 family. SWISS: P61073 Gene ID: 7852 Database links: Entrez Gene: 7852 Human Entrez Gene: 12767 Mouse Entrez Gene: 60628 Rat Omim: 162643 Human SwissProt: P61073 Human SwissProt: P70658 Mouse SwissProt: O08565 Rat Unigene: 593413 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. CXCR4是白细胞中的一种受体，在免疫系统中起着调整细胞运动的重要作用，目前多用于肿瘤细胞的生长、浸润性相关的研究。 |
| 产品图片 |  Sample: Brain (Rat) Lysate at 30 ug Heart (Rat) Lysate at 30 ug Primary: Anti- CXCR4 (bs-1011R) at 1/200 dilution Secondary: HRP conjugated Goat-Anti-rabbit IgG (bs-0295G-HRP) at 1/3000 dilution Predicted band size: 39 kD Observed band size: 39 kD  Sample: Lymph node(Mouse) Lysate at 40 ug Primary: Anti-CXCR4 (bs-1011R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 40 kD Observed band size: 40 kD |
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文献和实验相关实验
CXCR4, the receptor for stromal cell-derived factor (SDF)-1, was expressed in Saccharomyces cerevisiae coupled to the pheromone response pathway via a chimeric Gα subunit. Engagement of CXCR4 by SDF-1 resulted in expression of reporter genes
上海西唐生物科技有限公司 021-55229872, 65333639 www.westang.com 大鼠 Fusin(CXCR4)ELISA 试剂盒 ( 用于血清、血浆、细胞培养上清液和其它生物体液内 ) 原理 本实验采用双抗体夹心 ABC-ELISA 法。用抗大鼠 CXCR4 单抗包被于酶标板上，标准品和样品中的 CXCR4 与单抗结合，加入生物素化的抗大鼠 CXCR4 ，形成免疫复合
上海西唐生物科技有限公司 021-55229872, 65333639 www.westang.com 小鼠CXCR4 ( CXCR - 4 )ELISA 试剂盒 ( 用于血清、血浆、细胞培养上清液和其它生物体液内 ) 原理 本实验采用双抗体夹心 ABC-ELISA 法。用抗小鼠趋化因子受体-4( CXCR4 )单抗包被于酶标板上，标准品和样品中的 CXCR4
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CXCR4 antibody
¥780 - 2200
