The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This gene is preferentially expressed in a variety of hematopoietic cells, and is an early response gene in lymphokine stimulated cells. The noncatalytic N-terminus of this PTP can interact with MAP kinases and suppress the MAP kinase activities. This PTP was shown to be involved in the regulation of T cell antigen receptor (TCR) signaling, which was thought to function through dephosphorylating the molecules related to MAP kinase pathway. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Gene Description:
protein tyrosine phosphatase, non-receptor type 7
Gene Alias:
BPTP-4,HEPTP,LC-PTP,LPTP,PTPNI
Gene Name:
PTPN7
Protein Accession#:
NP_002823;P35236
Note:
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage Instruction:
Store at 4°C. For long term storage store at -20°C. Aliquot to avoid repeated freezing and thawing.
Storage Buffer:
In PBS (0.09% sodium azide)
Recommend Usage:
Western Blot (1:1000) Immunohistochemistry (1:10-50) The optimal working dilution should be determined by the end user.
Purification:
Protein A purification
Form:
Liquid
Reactivity:
Human
Host:
Rabbit
Immunogen:
A synthetic peptide (conjugated with KLH) corresponding to residues surrounding S44 of human PTPN7.
Product Description:
Rabbit polyclonal antibody raised against synthetic peptide of PTPN7.