The protein encoded by this gene belongs to the Bcl-2 family. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified. The longer gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene product (isoform 2) promotes apoptosis and is death-inducing. [provided by RefSeq
Gene Description:
myeloid cell leukemia sequence 1 (BCL2-related)
Gene Alias:
BCL2L3,EAT,MCL1L,MCL1S,MGC104264,MGC1839,TM
Gene Name:
MCL1
Note:
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage Instruction:
Store at -20°C. Aliquot to avoid repeated freezing and thawing.
Storage Buffer:
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Recommend Usage:
ELISA (1:2000) Western Blot (1-3 ug/mL) The optimal working dilution should be determined by the end user.
Quality Control Testing:
Antibody Reactive Against Synthetic Peptide.
Concentration:
0.5 mg/mL
Purification:
Antigen affinity purification
Form:
Liquid
Specificity:
This antibody is expected to recognize isoform 1 (NP_068779.1).
Reactivity:
Human, Mouse, Rat
Theoretical MW (kDa):
37.3
Host:
Goat
Sequence:
C-AGVGAGLAYLIR
Immunogen:
A synthetic peptide corresponding to human MCL1.
Product Description:
Goat polyclonal antibody raised against synthetic peptide of MCL1.