This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein is processed by caspase APAF1; this step is thought to be one of the earliest in the caspase activation cascade. Alternative splicing results in two transcript variants which encode different isoforms. [provided by RefSeq
Gene Description:
caspase 9, apoptosis-related cysteine peptidase
Gene Alias:
APAF-3,APAF3,CASPASE-9c,ICE-LAP6,MCH6
Gene Name:
CASP9
Protein Accession#:
NP_001220;P55211
Note:
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage Instruction:
Store at 4°C. For long term storage store at -20°C. Aliquot to avoid repeated freezing and thawing.
Storage Buffer:
In PBS (0.09% sodium azide)
Recommend Usage:
Western Blot (1:1000) Immunohistochemistry (1:50-100) The optimal working dilution should be determined by the end user.
Purification:
Protein G purification
Form:
Liquid
Reactivity:
Human
Host:
Rabbit
Immunogen:
Synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding S196 of human CASP9.
Product Description:
Rabbit polyclonal antibody raised against synthetic phosphopeptide of CASP9.