This antibody is produced by immunizing mice with a synthetic peptide (KLH-coupled) corresponding to HSP60.
Gene ID
3329
SwissProt
P10809
Synonyms
CPN60; CHAPERONIN 60-KD; GroEL E. COLI HOMOLOG OF HEAT-SHOCK 60-KD PROTEIN1; heat shock 60kDa protein 1 (chaperonin)
Category
Protein Folding and Trafficking
Background
The 60 kDa heat shock protein (HSP60) is a highly conserved protein that acts as a chaperone involved in correct folding of newly synthesized proteins. Mainly expressed in mitochondria, HPS60 has also been found in the cytosol of normal heart and muscle cells. The HSP60 proteins are abundant in the cell and are highly conserved between bacteria and human, with 50%-60% sequence homology. Mammalian HSP60 is expressed in the mitochondria at a low level and rapidly up-regulated under stresses, such as heat shock, and on some occasions with changes in intracellular location including expression on the cell surface.