北京重组小鼠PD-1(程序化细胞死亡蛋白1)厂家

特别声明：本产品及我公司所售其他产品均为科研类试剂产品，严禁用于药物、医疗及其他非科研用途。

北京百奥莱博专业生产供应北京重组小鼠PD-1(程序化细胞死亡蛋白1)厂家，我公司销*(代"售")全品类的分子生物学试剂，价格优惠，欢迎广大科研工作者垂询订购。

名称：北京重组小鼠PD-1(程序化细胞死亡蛋白1)厂家
产地：国产|进口
品牌：百奥莱博
编号：JN1895
规格：10μg|50μg|500μg|1mg
本品由我们的哺乳动物细胞表达系统制备而成，目的基因编码的Leu25-Gln167在C端含有His标签。

PD-1质量控制：＞95%(还原性SDS-PAGE)

PD-1制剂：冻干品

PD-1保存：
冻干蛋白置于-20℃以下可长期保存，室温条件下可稳定保存3周。
复溶蛋白溶液可在4～7℃保存2～7天，可分装后置于-20℃保存三个月。

PD-1复溶：
打开试剂管前请先离心。
复溶浓度推荐大于100 μg/ml。
冻干蛋白请溶于ddH2O。
复溶后，请根据用量分装冻存，避免反复冻融。

关于PD-1：
Programmed Death-1 (PD-1), firstly cloned from mouse T cell hybridoma 2B4.11, is one member of CD28/CTLA-4 superfamily. PD-1 belongs to type I transmembrane protein and acts as an important immunosuppressive molecule. The cytoplamsic tail of PD-1 contains two structural motifs, an immunoreceptor tyrosine-based inhibitory motif (ITIM) and an immunoreceptor tyrosine-based switch motif (ITSM) formed by two tyrosine residues which make the difference in PD-1 signal mediating.Mouse PD-1 is expressed in thymus and shares about 69% aa sequence identity with human PD-1. Recently, programmed death-1 (PD-1) with its ligands, programmed death ligand B7H1 (PD-L1) and B7DC (PD-L2), was found to regulate T-cell activation and tolerance, upon ligand binding, inhibiting T-cell effector functions in an antigen-specific manner.PD-1 gene knocked out mice would induce some autoimmune diseases, which suggests that PD-1 acts as a co-inhibitory molecule actively participating in maintaining peripheral tolerance. Thus, PD-1 may be a useful target for the immunologic therapy of carcinoma,infection,autoimmune diseases as well as organ transplantation.

北京重组小鼠PD-1(程序化细胞死亡蛋白1)厂家极具性价比，此外，我公司正火爆促销以下产品：

·重组人白介素IL-7(白细胞介素7)
编号：JN0349
英文名称：Recombinant Human Interleukin-7
规格：10μg|50μg|500μg|1mg
本品由我们的大肠杆菌表达系统制备，目的基因编码的Asp26-His177表达纯化而来。

IL-7质量控制：＞95%(还原性SDS-PAGE)。

IL-7制剂：冻干品

IL-7保存：
冻干蛋白可在-20℃长期保存，室温也可稳定保存3周。
复溶蛋白溶液可在4～7℃保存2～7天。
复溶后建议分装冻存在-20℃，可保存3个月，应避免反复冻融。

IL-7复溶：
1、试剂开盖前请先离心。
2、复溶浓度应大于100 μg/ml.
3、冻干蛋白溶于ddH2O中
4、复溶后根据使用量分装保存，避免反复冻融。

关于IL-7：
Human Interleukin 7 (IL-7) is a potent lymphoid cell growth factor stimulating the proliferation of lymphoid progenitors. IL7 can associate with the hepatocyte growth factor (HGF) to form a hybrid cytokine that functions as a pre-pro-B cell growth-stimulating factor. Human IL7 cDNA encodes a 177 amino acid precursor protein containing a 25 amino acid signal peptide and a 152 amino acid mature protein. Human and mouse IL7 share 65% sequence identity in the mature region and both exhibit cross-species activity. IL-7 signals via IL-7 receptor (IL7R) activating multiple pathways including JaK/STAT and PI3K/AKT, which regulate lymphocyte survival, glucose uptake, proliferation, and differentiation. IL-7 is also associated with cytoplasmic IL2-R gamma for signal transduction.


北京重组小鼠PD-1(程序化细胞死亡蛋白1)厂家关键词：重组小鼠程序化细胞死亡蛋白1,重组PD-1,重组小鼠PD-1,JN1895,重组小鼠PD-1蛋白


·重组小鼠激活素受体1B(ALK-4)
编号：JN1469
英文名称：Recombinant Mouse Activin Receptor Type-1B
规格：10μg|50μg|500μg|1mg
本品由我们的哺乳动物细胞表达系统制备而成，目的基因编码的Leu32-Glu126在C端带有Fc标签。

Activin RIB/ALK-4 质量控制：＞95%(还原性SDS-PAGE)

Activin RIB/ALK-4 制剂：冻干品

Activin RIB/ALK-4 保存：
冻干蛋白置于-20℃以下可长期保存，室温条件下可稳定保存3周。
复溶蛋白溶液可在4～7℃保存2～7天，可分装后置于-20℃保存三个月。

Activin RIB/ALK-4 复溶：
打开试剂管前请先离心。
复溶浓度推荐大于100 μg/ml。
冻干蛋白请溶于ddH2O。
复溶后，请根据用量分装冻存，避免反复冻融。

关于Activin RIB/ALK-4 ：
Activin Receptor Type-1B (ACVR1B) is a single-pass type I membrane protein that belongs to the protein kinase superfamily. ACVR1B contains one GS domain and one protein kinase domain and is expressed in many tissues, most strongly in kidney, pancreas, brain, lung, and liver. ACVR1B acts as a transducer of activin or activin like ligands signals. Activin binds to either ACVR2A or ACVR2B and then forms a complex with ACVR1B, ACVR2A or ACVR2B activating ACVR1B through phosphorylation of its regulatory GS domain. They go on to recruit the R-SMADs, SMAD2 and SMAD3. ACVR1B also transducers signals of nodal, GDF-1, and Vg1. Mutations in ACVR1B are associated with pituitary tumors.


北京重组小鼠PD-1(程序化细胞死亡蛋白1)厂家关键词：重组小鼠程序化细胞死亡蛋白1,重组PD-1,重组小鼠PD-1,JN1895,重组小鼠PD-1蛋白

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我公司正在打折促销重组蛋白全系列产品，恭候您的咨询选购北京重组小鼠PD-1(程序化细胞死亡蛋白1)厂家。