重组人S100A12(S100钙结合蛋白A12)说明书

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重组人S100A12(S100*结合蛋白A12)说明书是高品质的重组蛋白产品，由北京百奥莱博供应，用于生化科学研究，本产品质量好，且极具价格优势，深为用户称道，了解更多重组人S100A12(S100*结合蛋白A12)等重组蛋白产品请联*(代"系")我司咨询订购。

名称：重组人S100A12(S100*结合蛋白A12)说明书
规格：10μg|50μg|500μg|1mg
编号：JN1298
产地：国产|进口
品牌：百奥莱博
英文名：Recombinant Human S100 calcium-binding protein A12
本品由我们的大肠杆菌表达系统制备而成，目的基因编码的Met1-Glu92表达纯化得来。

S100A12质量控制：＞95%(还原性SDS-PAGE)

S100A12制剂：冻干品

S100A12保存：
冻干蛋白置于-20℃以下可长期保存，室温条件下可稳定保存3周。
复溶蛋白溶液可在4～7℃保存2～7天，可分装后置于-20℃保存三个月。

S100A12复溶：
打开试剂管前请先离心。
复溶浓度推荐大于100 μg/ml。
冻干蛋白请溶于ddH2O。
复溶后，请根据用量分装冻存，避免反复冻融。

关于S100A12：
Human EN-RAGE belongs to the S100/calgranulin superfamily. There are at least 21 different S100 proteins and the protein is 100% soluble in ammonium sulfate at neutral pH. S100 proteins play a role in regulation of protein phosphorylation, transcription factors, the dynamics of cytoskeleton constituents, enzyme activities, cell growth and differentiation, and the inflammatory response.Human EN-RAGE is characterized by two EF-hand calcium-binding motifs, zinc- and copper-binding protein.S100A12 is a disulfide-linked homodimer and the interface between the two subunits is composed mostly of hydrophobic residues.Its proinflammatory activity involves recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. EN-RAGE acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to receptor for advanced glycation endproducts (AGER). Binding to AGER activates the MAP-kinase and NF-kappa-B signaling pathways leading to production of proinflammatory cytokines and up-regulation of cell adhesion molecules ICAM1 and VCAM1. It also acts as a monocyte and mast cell chemoattractant. Moreover, it can stimulate mast cell degranulation and activation which generates chemokines, histamine and cytokines inducing further leukocyte recruitment to the sites of inflammation. It can inhibit the activity of matrix metalloproteinases; MMP2, MMP3 and MMP9 by chelating Zn2+from their active sites.

想要了解更多关于重组人S100A12(S100*结合蛋白A12)说明书的价格、品牌、厂家、说明书、促销信息，请和我们联*(代"系")。此外我公司还销*(代"售")下面的产品：
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重组人S100A12(S100*结合蛋白A12)说明书关键词：重组人S100*结合蛋白A12,JN1298,重组S100A12,重组人S100A12蛋白


·重组人脂肪酸结合蛋白3(FABP3)
编号：JN1931
英文名称：Recombinant Human Fatty Acid-Binding Protein 3
规格：10μg|50μg|500μg|1mg
本品由我们的大肠杆菌表达系统制备而成，目的基因编码的Val2-Ala133在N端含有His标签。

FABP3质量控制：＞95%(还原性SDS-PAGE)

FABP3制剂：冻干品

FABP3保存：
冻干蛋白置于-20℃以下可长期保存，室温条件下可稳定保存3周。
复溶蛋白溶液可在4～7℃保存2～7天，可分装后置于-20℃保存三个月。

FABP3复溶：
打开试剂管前请先离心。
复溶浓度推荐大于100 μg/ml。
冻干蛋白请溶于ddH2O。
复溶后，请根据用量分装冻存，避免反复冻融。

关于FABP3：
Fatty Acid Binding Protein 3 (FABP3) is a small cytoplasmic protein (15 kDa) that is released from cardiac myocytes following an ischemic episode. Like the nine other distinct FABPs that have been identified, FABP3 is involved in active fatty acid metabolism where it transports fatty acids from the cell membrane to mitochondria for oxidation. FABPs are divided into at least three distinct types, namely the hepatic-, intestinal- and cardiac-types. They form 14-15 kDa proteins and are thought to participate in the uptake, intracellular metabolism and/or transport of long-chain fatty acids. They may also be responsible in the modulation of cell growth and proliferation. The FABP3 gene contains four exons and its function is to arrest growth of mammary epithelial cells. This gene is also a candidate tumor suppressor gene for human breast cancer. FABP3 is a sensitive biomarker for myocardial infarction and can be detected in the blood within one to three hours of onset of pain.


重组人S100A12(S100*结合蛋白A12)说明书关键词：重组人S100*结合蛋白A12,JN1298,重组S100A12,重组人S100A12蛋白

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