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- 详细信息
- 文献和实验
- 技术资料
- 库存:
788
- 英文名:
Recombinant Mouse Death Receptor 6
- 保质期:
长期
- 供应商:
北京百奥莱博科技有限公司
- 保存条件:
冻干蛋白置于-20℃
特别声明:本产品及我公司所售其他产品均为科研类试剂产品,严禁用于药物、医疗及其他非科研用途。
北京百奥莱博专业生产销*(代"售")重组小鼠DR6(TNFRSF21)打折促销,我公司供应的分子生物学试剂品类齐全,且具有优势价格,欢迎新老客户垂询订购。
名称:重组小鼠DR6(TNFRSF21)打折促销
规格:10μg|50μg|500μg|1mg
英文名:Recombinant Mouse Death Receptor 6
编号:JN0465
产地:国产|进口
本品由我们的哺乳动物细胞表达系统制备而成,目的基因编码的Gln42-His349在C端含有Fc标签和His标签
DR6/TNFRSF21质量控制:>95%(还原性SDS-PAGE)
DR6/TNFRSF21制剂:冻干品
DR6/TNFRSF21保存:
冻干蛋白置于-20℃以下可长期保存,室温条件下可稳定保存3周。
复溶蛋白溶液可在4~7℃保存2~7天,可分装后置于-20℃保存三个月。
DR6/TNFRSF21复溶:
打开试剂管前请先离心。
复溶浓度推荐大于100 μg/ml。
冻干蛋白请溶于ddH2O。
复溶后,请根据用量分装冻存,避免反复冻融。
关于DR6/TNFRSF21:
Tumor necrosis factor receptor superfamily member 21(DR6) is a single-pass type I membrane protein and contains 1 death domain and 4 TNFR-Cys repeats. The protein may activate NF-kappa-B and promote apoptosis and it may activate JNK and be involved in T-cell differentiation.It is required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6).
我公司的重组小鼠DR6(TNFRSF21)打折促销,性价比高,货期短,送货上门,欢迎您来电咨询购买,另外,我公司还生产供应销*(代"售")下列产品:
·重组人肿瘤坏死因子配体超家族成员15(TNFSF15)
编号:JN0439
英文名称:Recombinant Human Tumor Necrosis Factor Ligand Superfamily Member 15
规格:10μg|50μg|500μg|1mg
本品由我们的大肠杆菌表达系统制备而成,目的基因编码的Met1-Leu192表达纯化得来。
TNFSF15质量控制:>95%(还原性SDS-PAGE)
TNFSF15制剂:冻干品
TNFSF15保存:
冻干蛋白置于-20℃以下可长期保存,室温条件下可稳定保存3周。
复溶蛋白溶液可在4~7℃保存2~7天,可分装后置于-20℃保存三个月。
TNFSF15复溶:
打开试剂管前请先离心。
复溶浓度推荐大于100 μg/ml。
冻干蛋白请溶于ddH2O。
复溶后,请根据用量分装冻存,避免反复冻融。
关于TNFSF15:
Tumor Necrosis Factor Ligand Superfamily Member 15 (TNFSF15) is a new member of the tumor necrosis factor family. TNFSF15 is predominantly an endothelial cell-specific gene, and recombinant TNFSF15 is a potent inhibitor of endothelial cell proliferation, angiogenesis and tumor growth. TNFSF15 exerts two activities on endothelial cells: early G1 arrest of G0/G1-cells responding to growth stimuli and programmed cell death of proliferating cells. These activities are highly specific to endothelial cells. TNFSF15 is also able to regulate the expression of several important genes involved in angiogenesis. These findings are consistent with the view that TNFSF15 functions as an autocrine cytokine to inhibit angiogenesis and stabilize the vasculature.
重组小鼠DR6(TNFRSF21)打折促销关键词:JN0465,重组DR6,重组小鼠TNFRSF21,重组小鼠DR6,重组小鼠DR6蛋白
·重组人Serpin A5(丝*酸蛋白酶抑制剂A5)
编号:JN1703
英文名称:Recombinant Human Serine Protease Inhibitor-clade A5
规格:10μg|50μg|500μg|1mg
本品由我们的哺乳动物细胞表达系统制备而成,目的基因编码的His20-Pro406在C端含有His标签。
Serpin A5质量控制:>95%(还原性SDS-PAGE)
Serpin A5制剂:冻干品
Serpin A5保存:
冻干蛋白置于-20℃以下可长期保存,室温条件下可稳定保存3周。
复溶蛋白溶液可在4~7℃保存2~7天,可分装后置于-20℃保存三个月。
Serpin A5复溶:
打开试剂管前请先离心。
复溶浓度推荐大于100 μg/ml。
冻干蛋白请溶于ddH2O。
复溶后,请根据用量分装冻存,避免反复冻融。
关于Serpin A5:
Serpin A5 is a member of the human Serpin superfamily consists of at least 35 members. It is synthesized in the liver and has been detected in saliva, cerebral spinal fluid, amniotic fluid, tears and semen. As a potent inhibitor of the protein C anticoagulant pathway at the levels of both zymogen activation and enzyme inhibition, Serpin A5 additionally inhibits a variety of serine protease including thrombin, factor Xa, several kallekreins and acrosin. It plays a critical role in the processes of blood of blood coagulation and fertilization. Serpin A5 also inhibits urinary plasminogen activator (uPA), a mediator of tumor cell invasion, and regulates tumor growth and metastasis by inhibiting angiogenesis. Furthermore, recent studies have identified PCI as a potent and direct inhibitor of activated HGFA (hepatocyte growth factor activator), suggesting a novel function in the regulation of tissue repair and regeneration. Similar to Serpins C1 and D1, the thrombin inhibitory activity of serpinA5 is enhanced by heparin.
重组小鼠DR6(TNFRSF21)打折促销关键词:JN0465,重组DR6,重组小鼠TNFRSF21,重组小鼠DR6,重组小鼠DR6蛋白
·重组人泛素结合酶E2-G2(UBCE2G2)
编号:JN0855
英文名称:Recombinant Human Ubiquitin-Conjugating Enzyme E2 G2
规格:10μg|50μg|500μg|1mg
本品由我们的大肠杆菌表达系统制备而成,目的基因编码的Met1-Leu165在N端带有GST标签。
UBE2G2质量控制:>95%(还原性SDS-PAGE)
UBE2G2制剂:液体
UBE2G2保存:收到货后请置于-20℃,可保存6个月,避免反复冻融。
关于UBE2G2:
Ubiquitin-Conjugating Enzyme E2 G2 (UBE2G2) is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation, which belong to the ubiquitin-conjugating enzyme family. It shares 60% and 100% sequence identity with S.cerevisiae Ubc7 and mouse respectively. The UBE2G2 enzyme and the GP78 E3 ligase are active components of endoplasmic reticulum-associated degradation pathway which is essential for the degradation of misfolded ER proteins. The mechanism of K48-linked poly-ubiquitination by UBE2G2/GP78 appears to involve the transfer of preassembled Ub chains from UBE2G2 to lysine residues in a substrate. The E2 and E3 enzymes form a large hetero-oligomer which brings multiple UBE2G2 molecules into close proximity which allows for Ub transfer between neighboring E2s.
北京百莱博科技有限公司专业生产重组蛋白产品,欢迎来电咨询选购重组小鼠DR6(TNFRSF21)打折促销。
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文献和实验【求助】求论文一篇---Nature:阿尔茨海默病发病机制研究
需要有caspase3参与,而轴突变性退化需要有caspase6参与,在轴突断裂的过程中caspase被激活。DR6可局部地被表面配机体激活,配机体由营养因子缺乏的状况下被释放出来,同时研究者还鉴定出APPl是DR6的配机体。营养因子缺乏会激发β分泌酶(BACE)依赖的APP从表面脱落。 功能研究发现DR6上链接APP的氨基端断裂会导致DR6变性。研究突变的小鼠发现遗传机制可证实这一现象的发生。 研究结果表明,APP和DR6是神经元自我摧毁过程中的重要效应
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