北京重组小鼠IgG1-Fc现货

特别声明：本产品及我公司所售其他产品均为科研类试剂产品，严禁用于药物、医疗及其他非科研用途。

北京百奥莱博专注于生命科学和生物技术领域，致力于为客户提供包括北京重组小鼠IgG1-Fc现货在内的一系列分子生物学试剂产品，并提供一系列相关的技术服务。

名称：北京重组小鼠IgG1-Fc现货
品牌：百奥莱博
编号：JN1161
规格：10μg|50μg|500μg|1mg
英文名：Recombinant Mouse Immunoglobulin G1 Fc
本品由我们的哺乳动物细胞表达系统制备而成，目的基因编码的Pro99-Lys324表达纯化得来。

IgG1-Fc质量控制：＞95%(还原性SDS-PAGE)

IgG1-Fc制剂：冻干品

IGHG1保存：
冻干蛋白置于-20℃以下可长期保存，室温条件下可稳定保存3周。
复溶蛋白溶液可在4～7℃保存2～7天，可分装后置于-20℃保存三个月。

IgG1-Fc复溶：
打开试剂管前请先离心。
复溶浓度推荐大于100 μg/ml。
冻干蛋白请溶于ddH2O。
复溶后，请根据用量分装冻存，避免反复冻融。

关于IgG1-Fc：
As a monomeric immunoglobulin that is predominately involved in the secondary antibody response and the only isotype that can pass through the human placenta, Immunoglobulin G (IgG) is synthesized and secreted by plasma B cells. IgG antibodies protect the body against the pathogens by agglutination and immobilization, complement activation, toxin neutralization, as well as the antibody-dependent cell-mediated cytotoxicity (ADCC). IgG tetramer contains two heavy chains (50 kDa ) and two light chains (25 kDa) linked by disulfide bonds, that is the two identical halves form the Y-like shape. IgG is digested by pepsin proteolysis into Fab fragment (antigen-binding fragment) and Fc fragment ("crystallizable" fragment). IgG1 is most abundant in serum among the four IgG subclasses (IgG1, 2, 3 and 4) and binds to Fc receptors (FcγR ) on phagocytic cells with high affinity.

更多有关北京重组小鼠IgG1-Fc现货的价格及使用说明等，请联*(代"系")我们的业务经理王欣女士咨询，我公司还销*(代"售")以下产品：

·重组小鼠TIGIT
编号：JN1625
英文名称：Recombinant Mouse T-cell immunoreceptor with Ig and ITIM domains
规格：10μg|50μg|500μg|1mg
本品由我们的哺乳动物细胞表达系统制备而成，目的基因编码的Gly26 - Thr143在C端带有Fc标签。

TIGIT质量控制：＞95%(还原性SDS-PAGE)

TIGIT制剂：冻干品

TIGIT保存：
冻干蛋白置于-20℃以下可长期保存，室温条件下可稳定保存3周。
复溶蛋白溶液可在4～7℃保存2～7天，可分装后置于-20℃保存三个月。

TIGIT复溶：
打开试剂管前请先离心。
复溶浓度推荐大于100 μg/ml。
冻干蛋白请溶于ddH2O。
复溶后，请根据用量分装冻存，避免反复冻融。

关于TIGIT：
T cell immunoreceptor with Ig and ITIM domains (TIGIT), also called WUCAM, VSIG9 and Vstm3, is a member of the CD28 family within the Ig superfamily of proteins. TIGIT contains an immunoglobulin variable domain, a transmembrane domain and an immunoreceptor tyrosine-based inhibitory motif (ITIM), and is expressed on regulatory, memory, activated T cells and NK cells. TIGIT binds to CD155(PVR) that appear on dendritic cells (DC), macrophages and endothelium with high affinity, and CD112(PVRL2) with lower affinity, but not CD113 (PVRL3). TIGIT-Fc fusion protein could interact with PVR on DC and enhance the secretion of IL-10, but inhibit the macrophage activation. Mice lacking TIGIT show increased T cell responses and susceptibility to autoimmune challenges, while knockdown of TIGIT with siRNA in human memory T cells did not affect T cell responses.


北京重组小鼠IgG1-Fc现货关键词：重组IgG1-Fc,JN1161,重组小鼠IgG1-Fc蛋白,百奥莱博,Recombinant Mouse Immunoglobulin G1 Fc


·重组小鼠CXCL9
编号：JN1605
英文名称：Recombinant Mouse C-X-C Motif Chemokine 9
规格：10μg|50μg|500μg|1mg
本品由我们的大肠杆菌表达系统制备而成，目的基因编码的Thr22­Thr126 表达纯化得来。

CXCL9质量控制：＞95%(还原性SDS-PAGE)

CXCL9制剂：冻干品

CXCL9保存：
冻干蛋白置于-20℃以下可长期保存，室温条件下可稳定保存3周。
复溶蛋白溶液可在4～7℃保存2～7天，可分装后置于-20℃保存三个月。

CXCL9复溶：
打开试剂管前请先离心。
复溶浓度推荐大于100 μg/ml。
冻干蛋白请溶于ddH2O。
复溶后，请根据用量分装冻存，避免反复冻融。

关于CXCL9：
Chemokine (C-X-C motif) ligand 9 (CXCL9, MIG), is a small cytokine belonging to the CXC chemokine family. CXCL9 functions as one of the three ligands of chemokine receptor CXCR3 which is a G protein-coupled receptor found predominantly on T cells. It together with CXCL10 and CXCL11, may activate CXCR3 by binding to it. CXCL9 serves as a cytokine that affects the growth, movement, or activation state of cells that participate in immune and inflammatory response. It has been observed that tumour endothelial cells secrete high levels of CXCL9 in all, and CXCL10 in most melanoma metastases. it plays an important role in CD4+ T lymphocyte recruitment and development of CAV, MOMA-2+ macrophages are the predominant recipient-derived source of CXCL9, and recipient CD4 lymphocytes are necessary for sustained CXCL9 production and CAV development in this model.


北京重组小鼠IgG1-Fc现货关键词：重组IgG1-Fc,JN1161,重组小鼠IgG1-Fc蛋白,百奥莱博,Recombinant Mouse Immunoglobulin G1 Fc

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