特别声明:本产品及我公司所售其他产品均为科研类试剂产品,严禁用于药物、医疗及其他非科研用途。
北京百奥莱博主要从事生物试剂的生产和销*(代"售"),产品线涵盖JN1394型重组人冠蛋白6(Coronin-6)北京厂家现货在内的分子生物学试剂产品,还包括PCR及荧光定量PCR、核酸提取试剂盒类、样本核酸保护试剂、核酸提取、克隆与转化、蛋白纯化、蛋白检测、免疫组化、细胞凋亡与抗体等。
名称:JN1394型重组人冠蛋白6(Coronin-6)北京厂家现货
规格:10μg|50μg|500μg|1mg
产地:国产|进口
英文名:Recombinant Human Coronin-6
编号:JN1394
品牌:百奥莱博
本品由我们的大肠杆菌表达系统制备而成,目的基因编码的Met1-Asp237在N端含有His标签。
Coronin-6质量控制:>95%(还原性SDS-PAGE)
Coronin-6制剂:冻干品
Coronin-6保存:
冻干蛋白置于-20℃以下可长期保存,室温条件下可稳定保存3周。
复溶蛋白溶液可在4~7℃保存2~7天,可分装后置于-20℃保存三个月。
Coronin-6复溶:
打开试剂管前请先离心。
复溶浓度推荐大于100 μg/ml。
冻干蛋白请溶于ddH2O。
复溶后,请根据用量分装冻存,避免反复冻融。
关于Coronin-6:
Coronin 6, a newly identified member of the coronin family, is highly enriched at adult NMJs and regulates AChR clustering via modulating the interaction between receptors and the actin cytoskeletal network. Coronins are a family of conserved actin-binding proteins originally identified in the actin-rich structure of the amoeba Dictyostelium discoideum . To date, seven members of coronins have been identified in mammals, and most exhibit tissue-specific distribution patterns. Coronin 6 is prominently expressed in adult muscle and enriched at the NMJ. Studies with cultured myotubes reveal that Coronin 6 regulates both agrin- and laminin-induced AChR clustering and is important for anchoring AChRs onto the actin cytoskeleton. Also, both the C-terminal region and a conserved Arg29 residue at the N terminus of Coronin 6 are essential for its actin-binding activity and stabilization of AChR–cytoskeleton linkage. Importantly, in vivo knockdown of Coronin 6 in mouse skeletal muscle fibers leads to destabilization of AChR clusters, which demonstrates that Coronin 6 is a critical regulator of AChR clustering at the postsynaptic region of the NMJs through modulating the receptor-anchored actin cytoskeleton. The human Coronin 6 has five isoforms produced by alternative splicing, and tissue-specific expression of these isoforms are unclear.
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JN1394型重组人冠蛋白6(Coronin-6)北京厂家现货关键词:JN1394,重组人冠蛋白6,重组冠蛋白6,重组人冠蛋白6蛋白,重组人Coronin-6
·重组小鼠Ephrin-B2(Efnb2)
编号:JN1156
英文名称:Recombinant Mouse Ephrin-B2
规格:10μg|50μg|500μg|1mg
本品由我们的哺乳动物细胞表达系统制备而成,目的基因编码的Arg29-Glu227在C端含有Fc标签和His标签
Ephrin-B2/Efnb2质量控制:>95%(还原性SDS-PAGE)
Ephrin-B2/Efnb2制剂:冻干品
Ephrin-B2/Efnb2保存:
冻干蛋白置于-20℃以下可长期保存,室温条件下可稳定保存3周。
复溶蛋白溶液可在4~7℃保存2~7天,可分装后置于-20℃保存三个月。
Ephrin-B2/Efnb2复溶:
打开试剂管前请先离心。
复溶浓度推荐大于100 μg/ml。
冻干蛋白请溶于ddH2O。
复溶后,请根据用量分装冻存,避免反复冻融。
关于Ephrin-B2/Efnb2:
Ephrin-B2 is a single-pass type I membrane protein and it contains 1 ephrin RBD (ephrin receptor-binding) domain. Ephrin-B2 belongs to the ephrin (EPH) family and it is cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. The ephrins and EPH-related receptors contain the largest subfamily of receptor protein-tyrosine kinases and have been associated with mediating developmental events, particularly in the nervous system and in erythropoiesis. Based upon their structures and sequence relationships, ephrins are allocated into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. It also binds to receptor tyrosine kinase including EPHA4, EPHA3 and EPHB4 and together with EPHB4 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration.
JN1394型重组人冠蛋白6(Coronin-6)北京厂家现货关键词:JN1394,重组人冠蛋白6,重组冠蛋白6,重组人冠蛋白6蛋白,重组人Coronin-6
·重组小鼠L-乳酸脱*酶(LDHA)
编号:JN1284
英文名称:Recombinant Mouse L-lactate dehydrogenase
规格:10μg|50μg|500μg|1mg
本品由我们的哺乳动物细胞表达系统制备而成,目的基因编码的Met1-Phe332在C端含有His标签。
LDHA质量控制:>95%(还原性SDS-PAGE)
LDHA制剂:液体
LDHA保存:收到货后请置于-20℃,可保存6个月,避免反复冻融。
关于LDHA:
Mouse Lactate dehydrogenase A (LDHA) is a member of the LDH/MDH superfamily and LDH family. LDHA catalyzes the inter-conversion of pyruvate and L-lactate with concomitant inter-conversion of NADH and NAD+. LDHA is found in most somatic tissues, though predominantly in muscle tissue and tumours. It has also been shown that LDHA plays an important role in the development, invasion and metastasis of malignancies. Mutations in LDHA have been linked to exertional myoglobinuria.
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