产品编号bs-0027R
英文名称Melatonin Receptor 1A
中文名称褪黑素受体1A/松果体素受体1A抗体
别 名Mel 1A R; Mel1a melatonin receptor; Mel1a receptor; MEL-1A-R; Melatonin receptor type 1A; MelR; MR; MT 1; MT1; MTNR 1A; MTNR1A; Melatonin receptor 1A; MTR1A_HUMAN; MTR-1A.
Specific References (3) | bs-0027R has been referenced in 3 publications.[IF=2.08] Wang, S-J., et al. "Melatonin suppresses apoptosis and stimulates progesterone production by bovine granulosa cells via its receptors (MT1 and MT2)." Theriogenology 78.7 (2012): 1517-1526. WB ; Bovine. PubMed:22980085 [IF=3.04] Tabecka-Lonczyska, Anna, et al. "New insight on the role of melatonin receptors in reproductive processes of seasonal breeders on the example of mature male European bison (Bison bonasus, Linnaeus 1758)." Journal of Photochemistry and Photobiology B: Biology (2017). dot-blot, IHC-P ; Other Species. PubMed:28570908 [IF=10.39] Jang, Hoon, et al. "Synergistic effect of melatonin and ghrelin in preventing cisplatin‐induced ovarian damage via regulation of FOXO3a phosphorylation and binding to the p27Kip1 promoter in primordial follicles." Journal of Pineal Research (2017). IHC-P ; Mouse. PubMed:28658519
规格价格50ul/780元 购买 100ul/1380元 购买 200ul/2200元 购买 大包装/询价
说 明 书50ul 100ul 200ul
研究领域肿瘤 细胞生物 神经生物学 信号转导 细胞膜受体 新陈代谢
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Sheep, Guinea Pig,
产品应用ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 Flow-Cyt=3μg/Test IF=1:100-500 (石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量39kDa
细胞定位细胞膜
性 状Lyophilized or Liquid
浓 度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from the midlle of human MTR-1A:201-280/350 <Cytoplasmic>
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMedPubMed
产品介绍background:
This gene encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This receptor is a G-protein coupled, 7-transmembrane receptor that is responsible for melatonin effects on mammalian circadian rhythm and reproductive alterations affected by day length. The receptor is an integral membrane protein that is readily detectable and localized to two specific regions of the brain. The hypothalamic suprachiasmatic nucleus appears to be involved in circadian rhythm while the hypophysial pars tuberalis may be responsible for the reproductive effects of melatonin.
Function:
High affinity receptor for melatonin. Likely to mediates the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity.