- ¥1152
- 联迈生物
- LM7181-50μg
- 中国/上海
- 2025年07月09日
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- 详细信息
- 文献和实验
- 技术资料
- 库存：
大量
- 英文名：
Recombinant Human p16-INK4a
- 保质期：
一年
- 供应商：
上海联迈生物工程有限公司
- 保存条件：
-20℃或更低温度保存
- 规格：
50μg
| 产品编号 | 产品名称 | 产品包装 | 产品价格 |
| LM7181-50μg | Recombinant Human p16-INK4a | 50μg | 1152.00元 |
| Species | Gene ID | Accession | Source | Length | MW | Tag |
| Human | 1029 | LM42771 | E. coli | 156aa | 16.5kDa | － |
| About this Antibody | |
| Name | Recombinant Human p16-INK4a (Recombinant Human Cyclin-Dependent Kinase Inhibitor 2A, Isoform 1; rHup16-INK4a)；重组人细胞周期蛋白依赖激酶抑制剂2A，同工酶1 |
| Synonyms | ARF; CDK4I; CDKN2A; INK4a; MLM; p14ARF; p16; p19ARF; ARF; CDK4 inhibitor p16-INK4; CDK4IP14ARF; CDKN2; cell cycle negative regulator beta; CMM2P16-INK4A; Cyclin-dependent kinase 4 inhibitor A; cyclin-dependent kinase inhibitor 2A; cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4); INK4; INK4A; INK4a; MLMP16INK4; MTS-1; MTS1P14; Multiple tumor suppressor 1; p14; p14ARF; P16; p16; p16-INK4; p16INK4a; p16INK4A; P16INK4A; p16-INK4a; p19; P19; p19ARF; p19Arf; P19ARF; TP16 |
| Purity | >96% by SDS-PAGE and HPLC analyses. |
| Biological Activity | Data Not Available. |
| Physical Appearance | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Formulation | Lyophilized from a 0.2μm filtered concentrated solution in PBS, pH7.4. |
| Endotoxin | Less than 1EU/μg of rHuP16-INK4a as determined by LAL method. |
| Reconstitution | We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0mg/ml. Stock solutions should be apportioned into working aliquots and stored at ≤-20℃. Further dilutions should be made in appropriate buffered solutions. |
| Category | Others |
| Background | Cyclin-dependent kinase inhibitors (CDKIs) are proteins that bind to and inhibit the activity of CDKs. Two major classes of CDK inhibitors have been identified. The p16 family (p15, p16, p18 and p19) binds to and inhibits the activities of CDK4 and CDK6. The p21 family (p21, p27, p28 and p57) can bind to broad range of CDK-cyclin complexes and inhibit their activities. CDKIs are capable of suppressing growth, and several lines of evidence strongly suggest that at least some CDKIs may be tumor suppressor proteins. p16-INK4A is the member of p16 family and is encoded by CDKN2A gene in humans. It has three isoforms, which are wildly expressed but not detected in brain or skeletal muscle, except that isoform 3 is pancreas-specific. Defects in p16INK4A are a cause of Li-Fraumeni syndrome (LFS) and melanoma-astrocytoma syndrome (MASTS). |
| Amino Acid Sequence | MEPAAGSSME PSADWLATAA ARGRVEEVRA LLEAGALPNA PNSYGRRPIQ VMMMGSARVA ELLLLHGAEP NCADPATLTR PVHDAAREGF LDTLVVLHRA GARLDVRDAW GRLPVDLAEE LGHRDVARYL RAAAGGTRGS NHARIDAAEG PSDIPD |
| 产品编号 | 产品名称 | 包装 |
| LM7181-10μg | Recombinant Human p16-INK4a | 10μg |
| LM7181-50μg | Recombinant Human p16-INK4a | 50μg |
| LM7181-100μg | Recombinant Human p16-INK4a | 100μg |
| LM7181-1mg | Recombinant Human p16-INK4a | 1mg |
| - | 说明书 | 1份 |
-20℃或更低温度保存，至少一年有效。由于蛋白的每次冻融均会引起部分失活，所以首次配制成相应浓度的储存液后(请根据产品简介中Reconstitution一栏的信息配制储存液)，须分装后-20℃或更低温度冻存，以避免反复冻融。
注意事项:
由于有些塑料管壁对某些蛋白有较强的吸附作用，溶液中的蛋白很容易粘附在管壁上，并且粘附后的蛋白很难与管壁分离。而载体蛋白(Carrier protein，如0.1% BSA等)的主要作用是预先封闭塑料管壁上的蛋白结合位点，使细胞因子或重组蛋白不会粘附于管壁。所以一定要使用产品简介中Reconstitution一栏的信息配制储存液。
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文献和实验p16INK4A and Familial Melanoma
alterations affecting p16INK4A and cyclin D1 are so frequent in human cancers that inactivation of these proteins is believed to be necessary for tumor development. Broadly applicable anticancer therapies might be based on restoration of p16INK4A CDK
Analysis of p16INK4a and Integrated HPV Genomes as Progression Markers
that never develop a lesion. Only a small percentage of low-grade dysplasias finally grow out to invasive cancer. Several biomarkers can be used to identify lesions at risk for malignant progression. Overexpression of p16INK4a is induced by the viral oncoprotein E7
The INK4a/ARF Locus and Human Cancer
This review focuses on the role of the INK4a/ARF locus in human cancer. Several excellent related reviews have recently been published (1 –5 ). Rather than presenting protocols, this review will describe the current state of the field
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