重组小鼠趋化因子CCL2(MCP-1)(带His标签) 重组

特别声明：本产品及我公司所售其他产品均为科研类试剂产品，严禁用于药物、医疗及其他非科研用途。

北京百奥莱博专业生产销*(代"售")重组小鼠趋化因子CCL2(MCP-1)(带His标签) 重组蛋白，我公司供应的分子生物学试剂品类齐全，且具有优势价格，欢迎新老客户垂询订购。

名称：重组小鼠趋化因子CCL2(MCP-1)(带His标签) 重组蛋白
英文名：Recombinant Mouse C-C motif chemokine 2
品牌：百奥莱博
规格：10μg|50μg|500μg|1mg
编号：JN0332
产地：国产|进口
本品由我们的哺乳动物表达系统制备，目的基因编码的Gln24-Asn148在C端含有His标签。

CCL2/MCP-1质量控制：＞95%(还原性SDS-PAGE)。

CCL2/MCP-1制剂：液体

CCL2/MCP-1保存：
收到后请置于-20℃，可稳定保存6个月，避免反复冻融。

关于CCL2/MCP-1：
C-C motif chemokine 2 (CCL2) is a member of the C-C or β chemokine family. Mouse CCL2 shares 82% amino acid (aa) identity with rat CCL2 over the entire sequence, and 58%, 56%, 55%, 53% and 53% aa identity with human, equine, porcine, bovine and canine CCL2, respectively. Fibroblasts, glioma cells, smooth muscle cells, endothelial cells, lymphocytes and mononuclear phagocytes can produce CCL2 either constitutively or upon mitogenic stimulation, but monocytes and macrophages appear to be the major source. In addition to its chemotactic activity, CCL2 induces enzyme and cytokine release by monocytes, NK cells and lymphocytes, and histamine release by basophils that express its receptor, CCR2. Additionally, it promotes Th2 polarization in CD4+ T cells. CCL2-mediated recruitment of monocytes to sites of inflammation is proposed to play a role in the pathology of atherosclerosis, multiple sclerosis and allergic asthma.

想要了解更多关于重组小鼠趋化因子CCL2(MCP-1)(带His标签) 重组蛋白的价格、品牌、厂家、说明书、促销信息，请和我们联*(代"系")。此外我公司还销*(代"售")下面的产品：

·重组人内皮细胞蛋白C受体(EPCR)
编号：JN0522
英文名称：Recombinant Human Endothelial Protein C Receptor
规格：10μg|50μg|500μg|1mg
本品由我们的哺乳动物细胞表达系统制备而成，目的基因编码的Ser18-Ser210在C端含有His标签。

EPCR质量控制：＞95%(还原性SDS-PAGE)

EPCR制剂：冻干品

EPCR保存：
冻干蛋白置于-20℃以下可长期保存，室温条件下可稳定保存3周。
复溶蛋白溶液可在4～7℃保存2～7天，可分装后置于-20℃保存三个月。

EPCR复溶：
打开试剂管前请先离心。
复溶浓度推荐大于100 μg/ml。
冻干蛋白请溶于ddH2O。
复溶后，请根据用量分装冻存，避免反复冻融。

关于EPCR：
Endothelial Protein C Receptor (EPCR) is a Vitamin K-dependent Serine Protease that plays a major role in blood coagulation. Binding of Protein C to EPCR leads to the proteolytic activation of PAR1 (Protease-Activated Receptor 1) on endothelial cells and subsequent up-regulation of Protein C-induced genes. EPCR is a type I transmembrane glycoprotein in the CD1/MHC family. It is expressed most strongly in the endothelial cells of arteries and veins in heart and lung. Membrane bound EPCR is released by metalloproteolytic cleavage to generate the soluble receptor. The extracellular domain of human and mouse EPCR shares approximately 61% amino acid sequence homology. EPCR plays an important role in augmenting Protein C activation by the Thrombin-Thrombomodulin complex and in regulating blood coagulation and inflammation. EPCR is found primarily on endothelial cells. Deletion of EPCR function results in embryonic death, at least in part due to placental thrombosis.


重组小鼠趋化因子CCL2(MCP-1)(带His标签) 重组蛋白关键词：JN0332,重组小鼠MCP-1,重组小鼠趋化因子CCL2,带His标签,重组小鼠趋化因子CCL2蛋白


·重组TIGIT
编号：JN1542
英文名称：Recombinant Cynomolgus monkey T cell Immunoreceptor with Ig and ITIM domains
规格：10μg|50μg|500μg|1mg
本品由我们的哺乳动物细胞表达系统制备而成，目的基因编码的Met89-Pro209在C端含有His标签。

TIGIT质量控制：＞95%(还原性SDS-PAGE)

TIGIT制剂：冻干品

TIGIT保存：
冻干蛋白置于-20℃以下可长期保存，室温条件下可稳定保存3周。
复溶蛋白溶液可在4～7℃保存2～7天，可分装后置于-20℃保存三个月。

TIGIT复溶：
打开试剂管前请先离心。
复溶浓度推荐大于100 μg/ml。
冻干蛋白请溶于ddH2O。
复溶后，请根据用量分装冻存，避免反复冻融。

关于TIGIT：
T cell immunoreceptor with Ig and ITIM domains (TIGIT), also called VSIG9 and Vstm3, is a member of the CD28 family within the Ig superfamily of proteins. TIGIT contains an immunoglobulin variable domain, a transmembrane domain and an immunoreceptor tyrosine-based inhibitory motif (ITIM), and is expressed on regulatory, memory, activated T cells and NK cells. TIGIT binds to CD155(PVR) that appear on dendritic cells (DC), macrophages and endothelium with high affinity, and CD112(PVRL2) with lower affinity, but not CD113 (PVRL3). TIGIT-Fc fusion protein could interact with PVR on DC and enhance the secretion of IL-10, but inhibit the macrophage activation. Mice lacking TIGIT show increased T cell responses and susceptibility to autoimmune challenges, while knockdown of TIGIT with siRNA in human memory T cells did not affect T cell responses.


重组小鼠趋化因子CCL2(MCP-1)(带His标签) 重组蛋白关键词：JN0332,重组小鼠MCP-1,重组小鼠趋化因子CCL2,带His标签,重组小鼠趋化因子CCL2蛋白

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