北京重组人VRK3说明书

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北京百奥莱博专业生产销*(代"售")北京重组人VRK3说明书，我公司供应的分子生物学试剂品类齐全，且具有优势价格，欢迎新老客户垂询订购。

名称：北京重组人VRK3说明书
编号：JN1247
英文名：Recombinant Human Vaccinia-related kinase 3
规格：10μg|50μg|500μg|1mg
品牌：百奥莱博
产地：国产|进口
本品由我们的哺乳动物细胞表达系统制备而成，目的基因编码的Met1-Phe412在C端含有His标签。

VRK3质量控制：＞95%(还原性SDS-PAGE)

VRK3制剂：液体

VRK3保存：收到货后请置于-20℃，可保存6个月，避免反复冻融。

关于VRK3：
Inactive serine/threonine-protein kinase VRK3 is a 474 amino acids protein that belongs to the protein kinase superfamily, CK1 Ser/Thr protein kinase family and VRK subfamily. It contains a protein kinase domain. VRK3 is widely expressed in human tissues and the protein localizes to the nucleus. VRK3 regulates several transcription factors, nuclear envelope assembly, and chromatin condensation and is also required for cell cycle progression .

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·重组人BH3结构域凋亡诱导蛋白(BID)
编号：JN1912
英文名称：Recombinant Human BH3-Interacting Domain Death Agonist
规格：10μg|50μg|500μg|1mg
本品由我们的大肠杆菌表达系统制备而成，目的基因编码的Met1-Asp195表达纯化得来。

BID/BH3-interacting domain death agonist质量控制：＞95%(还原性SDS-PAGE)

BID/BH3-interacting domain death agonist制剂：液体

BID/BH3-interacting domain death agonist保存：收到货后请置于-20℃，可保存6个月，避免反复冻融。

关于BID/BH3-interacting domain death agonist：
BH3-Interacting Domain Death Agonist (BID) is a member of the Bcl-2 protein family which regulates outer mitochondrial membrane permeability. BID is a pro-apoptotic member that causes cytochrome c to be released from the mitochondria intermembrane space into the cytosol. Interaction of Bid with Bak causes altered mitochondrial membrane permeability. BID contains only the BH3 domain, which is required for its interaction with the Bcl-2 family proteins and for its pro-death activity. BID is susceptible to proteolytic cleavage by caspases, calpains, Granzyme B and cathepsins. It is an integrating key regulator of the intrinsic death pathway that amplifies caspase-dependent and caspase-independent execution of neuronal apoptosis. Therefore pharmacological inhibition of BID provides a promising therapeutic strategy in neurological diseases where programmed cell death is prominent, and also offer a new strategy for the treatment of acute renal failure associated with ischemia-reperfusion. BID receives direct inputs from a key regulator of the cell cycle arrest/DNA repair machinery (ATM), and therefore is an excellent candidate to coordinate genotoxic stress responses and apoptotic cell death. BID is a novel pro-apoptosis Bcl-2 family protein that is activated by caspase 8 in response to Fas/TNF-R1 death receptor signals. Deletion of BID inhibits carcinogenesis in the liver, although this genetic alteration promotes tumorigenesis in the myeloid cells. This is likely related to the function of BID to promote cell cycle progression into S phase. BID could be also involved in the maintenance of genomic stability by engaging at mitosis checkpoint.


北京重组人VRK3说明书关键词：重组VRK3,Recombinant Human Vaccinia-related kinase 3,百奥莱博,JN1247,重组人VRK3蛋白


·重组小鼠DR6(TNFRSF21)
编号：JN0465
英文名称：Recombinant Mouse Death Receptor 6
规格：10μg|50μg|500μg|1mg
本品由我们的哺乳动物细胞表达系统制备而成，目的基因编码的Gln42-His349在C端含有Fc标签和His标签

DR6/TNFRSF21质量控制：＞95%(还原性SDS-PAGE)

DR6/TNFRSF21制剂：冻干品

DR6/TNFRSF21保存：
冻干蛋白置于-20℃以下可长期保存，室温条件下可稳定保存3周。
复溶蛋白溶液可在4～7℃保存2～7天，可分装后置于-20℃保存三个月。

DR6/TNFRSF21复溶：
打开试剂管前请先离心。
复溶浓度推荐大于100 μg/ml。
冻干蛋白请溶于ddH2O。
复溶后，请根据用量分装冻存，避免反复冻融。

关于DR6/TNFRSF21：
Tumor necrosis factor receptor superfamily member 21(DR6) is a single-pass type I membrane protein and contains 1 death domain and 4 TNFR-Cys repeats. The protein may activate NF-kappa-B and promote apoptosis and it may activate JNK and be involved in T-cell differentiation.It is required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6).


北京重组人VRK3说明书关键词：重组VRK3,Recombinant Human Vaccinia-related kinase 3,百奥莱博,JN1247,重组人VRK3蛋白

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阿利新蓝染色液(pH1.0)   3×50ml|3×100ml
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L-蛋*醇 D-Homophenylalanine 2899-37-8
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BL1130 ELISA终止液
磷酸* 3-(2-Aminoethylamino)propyldimethoxymethylsilane 10377-52-3
PY02-235  T1N0肉汤  250克  
D-*甘*醇 IBA-K 56613-80-0

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