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- 详细信息
- 文献和实验
- 技术资料
- 库存:
757
- 英文名:
Recombinant Human Oncostatin M
- 保质期:
长期
- 供应商:
北京百奥莱博科技有限公司
- 保存条件:
冻干蛋白置于-20℃
特别声明:本产品及我公司所售其他产品均为科研类试剂产品,严禁用于药物、医疗及其他非科研用途。
重组人抑瘤素M(肿瘤抑制因子M)(Oncostatin M)(OSM)北京厂家是高品质的重组蛋白产品,由北京百奥莱博供应,用于科研实验,本产品质量好,且极具价格优势,深为用户称道,了解更多重组人抑瘤素M(肿瘤抑制因子M)(Oncostatin M)(OSM)等重组蛋白产品请联*(代"系")我司咨询订购。
名称:重组人抑瘤素M(肿瘤抑制因子M)(Oncostatin M)(OSM)北京厂家
规格:10μg|50μg|500μg|1mg
英文名:Recombinant Human Oncostatin M
产地:国产|进口
品牌:百奥莱博
编号:JN0657
本品由我们的大肠杆菌表达系统制备而成,目的基因编码的Ala26-Arg221在N端含有His标签。
Oncostatin M质量控制:>95%(还原性SDS-PAGE)
Oncostatin M制剂:冻干品
Oncostatin M保存:
冻干蛋白置于-20℃以下可长期保存,室温条件下可稳定保存3周。
复溶蛋白溶液可在4~7℃保存2~7天,可分装后置于-20℃保存三个月。
Oncostatin M复溶:
打开试剂管前请先离心。
复溶浓度推荐大于100 μg/ml。
冻干蛋白请溶于ddH2O。
复溶后,请根据用量分装冻存,避免反复冻融。
关于Oncostatin M:
Oncostatin M (OSM) is a glycoprotein belonging to the interleukin-6 family of cytokines that includes leukemia-inhibitory factor, granulocyte colony-stimulating factor, and interleukin 6. OSM encodes a growth regulator, which Inhibits the proliferation of a number of tumor cell lines. It stimulates proliferation of AIDS-KS cells. OSM regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. OSM is considered as a pleiotropic cytokine that initiates its biological activities through specific cell surface receptors. The low affinity LIF receptor that shares the similarity of containing protein gp130 has now been identified to be a component of a high- affinity OSM receptor that will transduce OSM signals. OSM has also been shown to play a role in both pro and anti-inflammatory actions. OSM may also be involved in many biometabolism processes including liver development, haematopoeisis, inflammation, bone formation and destruction and possibly CNS development.
我公司的重组人抑瘤素M(肿瘤抑制因子M)(Oncostatin M)(OSM)北京厂家,性价比高,货期短,送货上门,欢迎您来电咨询购买,另外,我公司还生产供应销*(代"售")下列产品:
·重组人EGFR(HER1)(表皮生长因子受体)(C端带His标签)
编号:JN1260
英文名称:Recombinant Human Epidermal Growth Factor Receptor
规格:10μg|50μg|500μg|1mg
本品由我们的哺乳动物细胞表达系统制备而成,目的基因编码的Leu25-Ser645在C端含有His标签。
EGFR/HER1质量控制:>95%(还原性SDS-PAGE)
EGFR/HER1制剂:冻干品
EGFR/HER1保存:
冻干蛋白置于-20℃以下可长期保存,室温条件下可稳定保存3周。
复溶蛋白溶液可在4~7℃保存2~7天,可分装后置于-20℃保存三个月。
EGFR/HER1复溶:
打开试剂管前请先离心。
复溶浓度推荐大于100 μg/ml。
冻干蛋白请溶于ddH2O。
复溶后,请根据用量分装冻存,避免反复冻融。
关于EGFR/HER1:
The EGFR subfamily of receptor tyrosine kinases is composed of EGFR, ErbB2, ErbB3 and ErbB4. The EGFR shares 43% - 44% aa sequence identity with the ECD of human EGFR subfamily. All these family members are type I transmembrane glycoproteins with an extracellular ligand binding domain. The extracellular ligand binding domain is containing two cysteine-rich domains separated by a spacer region and a cytoplasmic domain containing a membrane-proximal tyrosine kinase domain. Ligand binding could induce EGFR homodimerization and heterodimerization with ErbB2, resulting in cell signaling, heterodimerization tyrosine phosphorylation and kinase activation. It can bind EGF, amphiregulin, TGF-alpha, betacellulin, epiregulin, HB-EGF, epigen, and so on. Its signaling regulates multiple biological functions including cell proliferation, differentiation, motility, and apoptosis. EGFR can also be recruited to form heterodimers with the ligand-activated ErbB3 or ErbB4. EGFR is overexpressed in different tumors. Several anti-cancer drugs use EGFR as target.
重组人抑瘤素M(肿瘤抑制因子M)(Oncostatin M)(OSM)北京厂家关键词:JN0657,重组人OSM,重组人肿瘤抑制因子M,重组人抑瘤素M,重组人Oncostatin M
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重组人抑瘤素M(肿瘤抑制因子M)(Oncostatin M)(OSM)北京厂家关键词:JN0657,重组人OSM,重组人肿瘤抑制因子M,重组人抑瘤素M,重组人Oncostatin M
·重组人谷胱甘肽合成酶
编号:JN0902
英文名称:Recombinant Human Glutathione Synthetase
规格:10μg|50μg|500μg|1mg
本品由我们的大肠杆菌表达系统制备而成,目的基因编码的Ala2-Val474在C端含有His标签。
GSH Synthetase质量控制:>95%(还原性SDS-PAGE)
GSH Synthetase制剂:液体
GSH Synthetase保存:收到货后请置于-20℃,可保存6个月,避免反复冻融。
关于GSH Synthetase:
Glutathione Synthetase belongs to the eukaryotic GSH synthase family. Glutathione Synthetase is the second enzyme in the glutathione biosynthesis pathway. It catalyses the condensation of gamma-glutamylcysteine and glycine to form glutathione. Glutathione play an important role in a variety of biological functions, including detoxification of xenobiotics, protection of cells from oxidative damage by free radicals, and membrane transport. The protein functions as a homodimer to catalyze the second step of glutathione biosynthesis, which is the ATP-dependent conversion of gamma-L-glutamyl-L-cysteine to glutathione. Defects in Glutathione Synthetase can also cause the glutathione synthetase deficiency of erythrocytes, which is a mild form causing hemolytic anemia.
我公司正在火爆促销重组蛋白系列产品,欢迎您的垂询选购重组人抑瘤素M(肿瘤抑制因子M)(Oncostatin M)(OSM)北京厂家。
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文献和实验Joy Aho1, Michael O’Connor2, Elizabeth Hughes3, Thom Saunders3, Electra Coucouvanis1, and Jessie Ni1 摘要 在转基因和敲除研究中,维持多能性对利用小鼠胚胎干(ES)细胞至关重要。已经发现许多因子可以影响ES细胞的多能性,其中之一就表现在白血病抑制因子(LIF)对ES细胞培养的影响。关于抑瘤素M(OSM)能补偿LIF在ES细胞培养中的作用,对此存在不一致的报道。一些研究提示
分子量和电荷有所差别,分子量38~64kDa,IP8.6~9.2。LIF体外生物学功能似乎与糖基化程度无关,但糖基化是否影响LIF在体内稳定性和功能尚待确定。人和小鼠LIF在氨基酸水平上有78%同源性,人LIF对鼠源性细胞有相似的活性,而小鼠LIF对人的细胞则作用很弱。在氨基酸水平上,LIF与抑瘤素-M(oncostatin M,OSM)和睫状神经营养因子(CNTF)有一事实上的同源性,而且在蛋白质分子二级结构上也有相似之处。 3.LIF的受体 ILF受体α链为低亲和力受体,其结构属于
2021 年 8 月 25 日,北京医疗保障局公布,将基因甲基化检测纳入甲类医保服务项目及甲类工伤保险项目;同样在 9 月 24日,多款基因甲基化检测产品被纳入海南医保价格目录。 图 1 .北京市和海南省医保局发布新增医疗项目表(部分) 许多研究表明,肿瘤与一系列基因和表观遗传的异常改变有关。细胞生长和分裂过程中涉及到的关键通路发生了基因突变或表观遗传改变,就可能会诱导肿瘤的发生。在肿瘤细胞 DNA
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