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- prospecbio
- HCV-235
- 以色列
- 2025年07月11日
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- 详细信息
- 文献和实验
- 技术资料
- 库存：
大量
- 英文名：
Hepatitis C Virus NS5 Recombinant
- 保质期：
1年
- 供应商：
上海沪震实业有限公司
- 保存条件：
-20°C
- 规格：
100µg/500µg/1000µg
CATALOGUE NUMBER
HCV-235
INTRODUCTION
HCV is a small 50nm, enveloped, single-stranded, positive sense RNAvirus in the family Flaviviridae.HCV has a high rate of replication with approximately one trillion particles produced each day in an infected individual. Due to lack of proofreading by the HCV RNA polymerase, the HCV has an exceptionally high mutation rate, a factor that may help it elude the host's immune response. Hepatitis C virus is classified into six genotypes(1-6) with several subtypes within each genotype. The preponderance and distribution of HCV genotypes varies globally. Genotype is clinically important in determining potential response to interferon-based therapy and the required duration of such therapy. Genotypes 1 and 4 are less responsive to interferon-based treatment than are the other genotypes (2, 3, 5 and 6).
DESCRIPTION
The E.coli derived recombinant protein contains the HCV NS5a immunodominant regions, amino acids 2061-2302. The protein is fused with GST at N-terminus.PURIFICATION METHOD
HCV-NS5 protein was purified by proprietary chromatographic technique.PURITY
HCV-NS5 protein is >95% pure as determined by 10% PAGE (coomassie staining).FORMULATION
1.5M Urea, 25mM Tris-HCl pH 8, 50% glycerol and 0.2% Triton-X.STABILITY
HCV NS5 although stable at 4°C for 1 week, should be stored below -18°C.
Please prevent freeze thaw cycles.
SPECIFICITY
Immunoreactive with sera of HCV-infected individuals.APPLICATIONS
HCV-NS5 antigen is suitable for ELISA and Western blots, excellent antigen for detection of HCV with minimal specificity problems.USAGE
ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
文献和实验HCV Genotyping by the Line Probe Assay INNO-LiPA HCV II
which is co- and posttranslationally cleaved into at least nine proteins. Core, E1, and E2 (the structural proteins) and NS2, NS3, NS4A, NS4B, NS5A, and NS5B (the nonstructural [NS] proteins). A theoretical protein of 7 kDa (tp7) may be processed from the carboxy terminal E2 region (1 ).
Confirmation of HCV Antibodies by the Line Immunoassay INNO-LIA HCV Ab III
; NS2, NS3, NS4A, NS4B, NS5A, and NS5B are nonstructural (NS) proteins. HCV isolates display high levels of sequence heterogeneity allowing classification into at least 11 types and 90 subtypes (1 ). HCV infection of the human liver is often clinically
NS5A Phosphorylation and Hyperphosphorylation
NS5A phosphorylation can be studied in two ways: in living cells and in vitro. The former has several advantages: NS5A phosphorylation takes place in a cellular background and therefore might mimic more closely the real in vivo situation
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