α-Internexin

英文名称α-Internexin
中文名称α-中连蛋白抗体
别    名a-Internexin; Alpha-Internexin; Alpha-Internexin; 66 kDa neurofilament protein; Alpha Inx; INA; Internexin neuronal intermediate filament protein alpha; MGC12702; NEF 5; NEF5; Neurofilament 5 (66kD); Neurofilament 66; Neurofilament 66 tax binding protein; NF 66; NF66; NF-66; TXBP 1; TXBP1; AINX_HUMAN; Alpha-Inx; Neurofilament-66.  
研究领域神经生物学  干细胞  细胞粘附分子  细胞骨架  
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse, 
产品应用ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量55kDa
细胞定位细胞浆 
性    状Lyophilized or Liquid
浓    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human NF-66:251-350/499 
亚    型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMedPubMed
产品介绍background:
eurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and they functionally maintain the neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene is a member of the intermediate filament family and is involved in the morphogenesis of neurons. [provided by RefSeq, Jun 2009]

Function:
Class-IV neuronal intermediate filament that is able to self-assemble. It is involved in the morphogenesis of neurons. It may form an independent structural network without the involvement of other neurofilaments or it may cooperate with NF-L to form the filamentous backbone to which NF-M and NF-H attach to form the cross-bridges.

Subcellular Location:
Cytoplasmic.

Tissue Specificity:
Found predominantly in adult CNS.

Post-translational modifications:
O-glycosylated (By similarity).
Phosphorylated upon DNA damage, probably by ATM or ATR. 

Similarity:
Belongs to the intermediate filament family.

SWISS:
Q16352

Gene ID:
9118

Database links:
Entrez Gene: 9118 Human
Entrez Gene: 226180 Mouse
Entrez Gene: 24503 Rat
Omim: 605338 Human
SwissProt: Q16352 Human
SwissProt: P46660 Mouse
SwissProt: P23565 Rat
Unigene: 500916 Human
Unigene: 276251 Mouse
Unigene: 88941 Rat


Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.