Mothers Against Decapentaplegic Homolog 3 Human Recombinant
保质期:
1年
供应商:
上海沪震实业有限公司
保存条件:
-20°C
规格:
5μg/25μg/1mg
SMAD3 Human
CATALOGUE NUMBER
PRO-751
SYNONYMS
MADH3, JV15-2, HSPC193, HsT17436, MGC60396, DKFZp586N0721, DKFZp686J10186, SMAD3, Mothers against decapentaplegic homolog 3, Mothers against DPP homolog 3, MAD homolog 3, Mad3, hMAD-3, SMAD family member 3, SMAD 3, hSMAD3.
INTRODUCTION
SMAD3 is part of the SMAD family of proteins that mediate signal transduction by the TGF-beta/activin/BMP-2/4 cytokine superfamily from receptor Ser/Thr protein kinases at the cell surface to the nucleus. SMAD3 has a role as a transcriptional modulator activated by TGF-Beta and is involved in the regulation of carcinogenesis. SMAD3 mutations are related with the pathogenesis of human osteoarthritis. SMAD3 expression take part in tumor suppression in the premature stages of gastric carcinogenesis. SMAD3 is involved in nuclear translocation of beta-catenin.
DESCRIPTION
SMAD3 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 445 amino acids (1-425) and having a molecular mass of 50.2 kDa. SMAD3 is fused to a 20 amino acid His-Tag at N-Terminus and purified by standard chromatography techniques.
SOURCE
Escherichia Coli.
PHYSICAL APPEARANCE
Sterile Filtered colorless solution.
FORMULATION
The SMAD3 protein solution contains 20mM Tris-HCl pH-8, 0.1M NaCl, 0.1mM DTT and 20% glycerol.
STABILITY
Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Avoid multiple freeze-thaw cycles.
ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.