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- prospecbio
- ANT-131
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- 2025年07月14日
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- 详细信息
- 文献和实验
- 技术资料
- 库存：
大量
- 英文名：
CD8, Mouse Anti-Human
- 保质期：
1年
- 供应商：
上海沪震实业有限公司
- 保存条件：
-20°C
- 规格：
500µg/1mg
CATALOGUE NUMBER
ANT-131
SYNONYMS
CD8, MAL, p32.TYPE
Mouse Anti Human Monoclonal.INTRODUCTION
CD8 is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. CD8 acts as a co-receptor, and the T-cell receptor on the T lymphocyte recognize antigen displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional CD8 is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains.CD8 identifies cytotoxic/suppressor t-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of t-cell mediated killing. CD8 alpha chains binds to class-I MHC molecules alpha-3 domains.
CLONE
hCD8.IMMUNOGEN
Purified human PBL CD8+ T cells.IG SUBCLASS
Mouse IgG2a.PURIFICATION METHOD
Ion exchange column.FORMULATION
1mg/ml in PBS (after reconstitution).STORAGE PROCEDURES
Lyophilized: store at 4oC. After reconstitution, if not intended for use within a month, aliquot and store at -20oC.SOLUBILITY
Reconstitute with of H20. Mix gently, wash the sides of the vial and wait 30-60 seconds before use.APPLICATIONS
Staining antibody, weakly cytotoxic. For staining, use 10µl/1,000,000 cells. Titer for cytotoxicity should be determined by the investigator.AVAILABLE CONJUGATES
This antibody is also available conjugated to biotin.USAGE
Prospec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
文献和实验Purification of Immature CD4+CD8+ Thymocytes by Panning with Anti-CD8 Antibody
Most T lymphocytes of the immune system differentiate within the thymus along the CD4/CD8 developmental pathway by a highly ordered process termed thymic selection ( 1 , 2 ). The maturation status of thymocytes is commonly assessed
流式课堂 | 易被忽略的 CD4、CD8 共表达细胞——胸腺淋巴细胞
做过流式实验的同学，对 CD4、CD8 这两个指标都不会陌生。检测 CD4+ T 细胞和 CD8+ T 细胞分型，是流式中最常见的实验之一。 通常，我们会先检测 CD3，来圈总T淋巴细胞，再分别用 CD4 抗体和 CD8 抗体，来区分 CD4+ T 淋巴细胞（辅助或调节性T细胞）和 CD8+ T 淋巴细胞（细胞毒性 T 细胞）。 新生小鼠脾脏细胞 上图为新生小鼠脾脏细胞进行的 CD3-PE、CD4-FITC、CD8-APC 三色流式实验结果。从图中可以看出，在新生小鼠脾脏中，绝大
8.0) in clean 16x125mm polypropylene test tube. If needed, adjust pH to 8.0 using 0.5M carbonate buffer. 2. Prepare fresh, 1mg/mL of either NHS-FITC in DMSO or 1mg/mL NHS-LC-Biotin in DH2O. If FITC coupling, add 75uL of FITC/DMSO solution to Antibody
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