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- 详见说明书
- 详见说明书
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- 详细信息
- 文献和实验
- 技术资料
- 抗体名：
磷酸化细胞周期检控Rad17蛋白抗体
- 抗体英文名：
Anti-Phospho-Rad17 (Ser645)
- 靶点：
详见说明书
- 浓度：
1mg/1ml
- 应用范围：
WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
- 宿主：
详见说明书
- 供应商：
上海一研
- 库存：
45
- 级别：
详见说明书
- 目录编号：
详见说明书
- 抗原来源：
Rabbit
- 保质期：
详见说明书
- 适应物种：
详见说明书
- 标记物：
详见说明书
- 克隆性：
多克隆
- 保存条件：
Store at -20 °C
- 形态：
详见说明书
- 亚型：
IgG
- 免疫原：
KLH conjugated Synthesised phosphopeptide derived from human Rad17 around the phosphorylation site of Ser645
- 规格：
0.1ml/100μg
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英文名称 Anti-Phospho-Rad17 (Ser645)
中文名称 磷酸化细胞周期检控Rad17蛋白抗体说明书
别 名 CCYC; Cell cycle checkpoint protein; Cell cycle checkpoint protein RAD17; HRAD 17; HRAD17; R24L; Rad 17; Rad 24; RAD1 (S. pombe) homolog; RAD17 homolog; Rad17 like protein; RAD17Sp; Rad24; RF C activator 1 homolog; RF C/activator 1 homolog.
浓 度 1mg/1ml
规 格 0.1ml/100μg
抗体来源 Rabbit
克隆类型 polyclonal
交叉反应 Human, Mouse, Rat
产品类型 一抗 磷酸化抗体
研究领域 肿瘤 免疫学 信号转导 细胞周期蛋白 转录调节因子
蛋白分子量 predicted molecular weight: 77kDa
性 状 Lyophilized or Liquid
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from human Rad17 around the phosphorylation site of Ser645
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍 The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. This protein binds to chromatin prior to DNA damage and is phosphorylated by the checkpoint kinase ATR following damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be required for its phosphorylation. The phosphorylation of this protein is required for the DNA-damage-induced cell cycle G2 arrest, and is thought to be a critical early event during checkpoint signaling in DNA-damaged cells. Multiple alternatively spliced transcript variants of this gene, which encode four distinct protein isoforms, have been reported. Two pseudogenes, located on chromosomes 7 and 13, have been identified. [provided by RefSeq, Jul 2013].
Function : Essential for sustained cell growth, maintenance of chromosomal stability, and ATR-dependent checkpoint activation upon DNA damage. Has a weak ATPase activity required for binding to chromatin. Participates in the recruitment of the RAD1-RAD9-HUS1 complex and C12orf32/RHINO onto chromatin, and in CHEK1 activation. May also serve as a sensor of DNA replication progression, and may be involved in homologous recombination.
Subunit : Part of a DNA-binding complex containing RFC2, RFC3, RFC4 and RFC5. Interacts with RAD1 and RAD9 within the RAD1-RAD9-HUS1 complex. Interacts with RAD9B, POLE, NHP2L1 and MCM7. DNA damage promotes interaction with ATR or ATM and disrupts interaction with the RAD1-RAD9-HUS1 complex.
Subcellular Location : Nucleus. Note=Phosphorylated form redistributes to discrete nuclear foci upon DNA damage.
Tissue Specificity : Overexpressed in various cancer cell lines and in colon carcinoma (at protein level). Isoform 2 and isoform 3 are the most abundant isoforms in non irradiated cells (at protein level). Ubiquitous at low levels. Highly expressed in testis, where it is expressed within the germinal epithelium of the seminiferous tubuli. Weakly expressed in seminomas (testicular tumors).
Post-translational modifications : Phosphorylated. Phosphorylation on Ser-646 and Ser-656 is cell cycle-regulated, enhanced by genotoxic stress, and required for activation of checkpoint signaling. Phosphorylation is mediated by ATR upon UV or replication arrest, whereas it may be mediated both by ATR and ATM upon ionizing radiation. Phosphorylation on both sites is required for interaction with RAD1 but dispensable for interaction with RFC3 or RFC4.
Similarity : Belongs to the rad17/RAD24 family.
Database links : UniProtKB/Swiss-Prot: O7
磷酸化细胞周期检控Rad17蛋白抗体说明书储存温度：
存在于血清、组织培养上清液或腹水中的抗体在-20℃下能够长期储存。低温存放不会损伤抗体活性。抗体的工作液通常储存于4℃中。此温度下，抗体的活性能稳定数月至数年亦不损失。抗体溶液不应反复冻融，因为反复冻融将导致部分抗体失活并产生不需要的蛋白—蛋白凝聚物。抗体的凝聚能导致活性丧失。这是由于抗原结合位点的空间构象被破坏，或由于产生的不溶物被离心或过滤而除去。冷凝蛋白类的抗体不能存放于4℃。因为在4℃下此类抗体会发生沉淀。一些鼠源性IgG3亚类的抗体有此特性。如果抗体在4℃下发生沉淀，就应该存放于室温下的叠氮钠溶液中。
磷酸化细胞周期检控Rad17蛋白抗体说明书的分类：
按作用对象，可将其分为抗毒素、抗菌抗体、抗病毒抗体和亲细胞抗体（能与细胞结合的免疫球蛋白，如1型变态反应中的lgE反应素抗体，能吸附在靶细胞膜上）；按理化性质和生物学功能，可将其分为IgM、IgG、IgA、IgE、IgD五类；按抗体的来源，可 将其分为天然抗体和免疫抗体。抗体就是免疫球蛋白，是改变了的球蛋白分子。由特异性抗原刺激产生，抗体的产生是由于抗原侵入人体后引起各种免疫细胞相互作用，使淋巴细胞中的B细胞分化增殖而形成浆细胞，浆细胞可产生分泌抗体。
ADMR上髓质素受体抗体规格:0.1ml
RUNX1T1/ETO周期素D相关蛋白抗体规格:0.1ml
PRB2/p130视网膜母细胞瘤相关蛋白p130抗体规格:0.1ml
Connexin-45间隙连接蛋白45抗体规格:0.1ml
CyclinD1/FSTL3周期素D1抗体规格:0.1ml
PRODH脯氨酸脱酶抗体规格:0.2ml
Deltex-1DTX1抗体规格:0.2ml
RabbitAnti-GoatIgM/PE-Cy5.5PE-Cy5.5标记的兔抗羊IgM规格:0.1ml
S100B/S100betaS100B蛋白抗体0.2ml
5-HTR2B5-羟色胺受体2B抗体0.1mlig Endothelin-1 (1-38), human Cys-Ser-Cys-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys-Val-Tyr- Phe-Cys-His-Leu-Asp-Ile-Ile-Trp-Val-Asn-Thr-Pro-Glu-His-Val-Val-Pro-Tyr-Gly-Leu-Gly-Ser-Pro-Arg-Ser(Disulfide bridge:Cys1-Cys15, Cys3-Cys11)
Biotin-β-Endomorphin, human Biotin-Tyr-Gly-Gly-Phe-Met-Thr-Ser-Glu-Lys-Ser-Gln-Thr-Pro-Leu-Val-Thr-Leu-Phe-Lys-Asn-Ala-Ile-Ile-Lys-Asn-Ala-Tyr-Lys-Lys-Gly-Glu
Caerulein (desulfated) Pyr-Gln-Asp-Tyr-Thr-Gly-Trp-Met-Asp-Phe-NH2
Cecropin A (1-8)-Melittin (1-18) amide Lys-Trp-Lys-Leu-Phe-Lys-Lys-Ile-Gly-Ile-Gly-Ala-Val-Leu-Lys-Val-Leu-Thr-Thr-Gly-Leu-Pro-Ala-Leu-Ile-Ser-NH2
Crustacean Cardioactive Peptide (CCAP) Pro-Phe-Cys-Asn-Ala-Phe-Thr-Gly-Cys
Dynorphin A (1-6), porcine Tyr-Gly-Gly-Phe-Leu-Arg
Exendin 4 His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-磷酸化细胞周期检控Rad17蛋白抗体说明书Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2
Gastric Inhibitory Polypeptide (6-30) amide (human) Phe-Ile-Ser-Asp-Tyr-Ser-Ile-Ala-Met-Asp-Lys-Ile-His-Gln-Gln-Asp-Phe-Val-Asn-Trp-Leu-Leu-Ala-Gln-Lys-NH2
gp100 (570-579) Ser-Leu-Ala-Asp-Thr-Asn-Ser-Leu-Ala-Val
HER2//neu(654-662) GP2 Ile-Ile-Ser-Ala-Val-Val-Gly-Ile-Leu
Hypercalcemia Malignancy Factor (7-34), amide, human Leu-Leu-His-Asp-Lys-Gly-Lys-Ser-Ile-Gln-Asp-Leu-Arg-Arg-Arg-Phe-Phe-Leu-His-His-Leu-Ile-Ala-Glu-Ile-His-Thr-Ala-NH2
K-G-D-S Lys-Gly-Asp-Ser
磷酸化细胞周期检控Rad17蛋白抗体说明书按理化性质和生物学功能，可将其分为IgM、IgG、IgA、IgE、IgD五类。
IgM抗体是免疫应答中首先分泌的抗体。它们在与抗原结合后启动补体的级联反应。它们还把入侵者相互连接起来，聚成一堆便于巨噬细胞的吞噬；
IgG抗体激活补体，中和多种毒素。IgG持续的时间长，是 唯一能在母亲妊娠期穿过胎盘保护胎儿的抗体。他们还从乳腺分泌进入初乳，使新生儿得 到保护；
IgA抗体进入身体的黏 膜表面，包括呼吸、消化、生殖等管道的黏膜，中和感染因子。还可以通过母乳的初乳把这种抗体输送到新生儿的消化道黏膜中，是在母乳中含量最多，最为重要的一类抗体；
IgE抗体的尾部与嗜碱细胞、肥大细胞的细胞膜结合。当抗体与抗原结合后，嗜碱细胞与肥大细胞释放组织胺一类物质促进炎症的发展。这也是引发速发型过敏反应的抗体；
IgD抗体的作用还不太清楚。它们主要出现在成熟的B淋巴细胞表面上，可能与B细胞的分化有关。（IgD于1995年从人骨髓瘤蛋白中发现，分子量为175kD，主要由扁桃体、脾等处浆细胞产生，人血清中IgD浓度为3～40μg/ml,不到血清总Ig的1%，在个体发育中合成较晚。IgD铰链区很长，且对蛋白酶水解敏感，因此IgD半衰期很短，仅2.8天。血清中IgD确切的免疫功能尚不清楚。在B细胞分化到成熟B细胞阶段，除了表达SmIgD，抗原刺激后表现为免疫耐受。成熟B细胞活化后或者活化后或者变成记忆B细胞时，SmIgD逐渐消失。
英文名称 Anti-Phospho-Rad17 (Ser645)
中文名称 磷酸化细胞周期检控Rad17蛋白抗体说明书
别 名 CCYC; Cell cycle checkpoint protein; Cell cycle checkpoint protein RAD17; HRAD 17; HRAD17; R24L; Rad 17; Rad 24; RAD1 (S. pombe) homolog; RAD17 homolog; Rad17 like protein; RAD17Sp; Rad24; RF C activator 1 homolog; RF C/activator 1 homolog.
浓 度 1mg/1ml
规 格 0.1ml/100μg
抗体来源 Rabbit
克隆类型 polyclonal
交叉反应 Human, Mouse, Rat
产品类型 一抗 磷酸化抗体
研究领域 肿瘤 免疫学 信号转导 细胞周期蛋白 转录调节因子
蛋白分子量 predicted molecular weight: 77kDa
性 状 Lyophilized or Liquid
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from human Rad17 around the phosphorylation site of Ser645
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍 The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. This protein binds to chromatin prior to DNA damage and is phosphorylated by the checkpoint kinase ATR following damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be required for its phosphorylation. The phosphorylation of this protein is required for the DNA-damage-induced cell cycle G2 arrest, and is thought to be a critical early event during checkpoint signaling in DNA-damaged cells. Multiple alternatively spliced transcript variants of this gene, which encode four distinct protein isoforms, have been reported. Two pseudogenes, located on chromosomes 7 and 13, have been identified. [provided by RefSeq, Jul 2013].
Function : Essential for sustained cell growth, maintenance of chromosomal stability, and ATR-dependent checkpoint activation upon DNA damage. Has a weak ATPase activity required for binding to chromatin. Participates in the recruitment of the RAD1-RAD9-HUS1 complex and C12orf32/RHINO onto chromatin, and in CHEK1 activation. May also serve as a sensor of DNA replication progression, and may be involved in homologous recombination.
Subunit : Part of a DNA-binding complex containing RFC2, RFC3, RFC4 and RFC5. Interacts with RAD1 and RAD9 within the RAD1-RAD9-HUS1 complex. Interacts with RAD9B, POLE, NHP2L1 and MCM7. DNA damage promotes interaction with ATR or ATM and disrupts interaction with the RAD1-RAD9-HUS1 complex.
Subcellular Location : Nucleus. Note=Phosphorylated form redistributes to discrete nuclear foci upon DNA damage.
Tissue Specificity : Overexpressed in various cancer cell lines and in colon carcinoma (at protein level). Isoform 2 and isoform 3 are the most abundant isoforms in non irradiated cells (at protein level). Ubiquitous at low levels. Highly expressed in testis, where it is expressed within the germinal epithelium of the seminiferous tubuli. Weakly expressed in seminomas (testicular tumors).
Post-translational modifications : Phosphorylated. Phosphorylation on Ser-646 and Ser-656 is cell cycle-regulated, enhanced by genotoxic stress, and required for activation of checkpoint signaling. Phosphorylation is mediated by ATR upon UV or replication arrest, whereas it may be mediated both by ATR and ATM upon ionizing radiation. Phosphorylation on both sites is required for interaction with RAD1 but dispensable for interaction with RFC3 or RFC4.
Similarity : Belongs to the rad17/RAD24 family.
Database links : UniProtKB/Swiss-Prot: O7
磷酸化细胞周期检控Rad17蛋白抗体说明书储存温度：
存在于血清、组织培养上清液或腹水中的抗体在-20℃下能够长期储存。低温存放不会损伤抗体活性。抗体的工作液通常储存于4℃中。此温度下，抗体的活性能稳定数月至数年亦不损失。抗体溶液不应反复冻融，因为反复冻融将导致部分抗体失活并产生不需要的蛋白—蛋白凝聚物。抗体的凝聚能导致活性丧失。这是由于抗原结合位点的空间构象被破坏，或由于产生的不溶物被离心或过滤而除去。冷凝蛋白类的抗体不能存放于4℃。因为在4℃下此类抗体会发生沉淀。一些鼠源性IgG3亚类的抗体有此特性。如果抗体在4℃下发生沉淀，就应该存放于室温下的叠氮钠溶液中。
磷酸化细胞周期检控Rad17蛋白抗体说明书的分类：
按作用对象，可将其分为抗毒素、抗菌抗体、抗病毒抗体和亲细胞抗体（能与细胞结合的免疫球蛋白，如1型变态反应中的lgE反应素抗体，能吸附在靶细胞膜上）；按理化性质和生物学功能，可将其分为IgM、IgG、IgA、IgE、IgD五类；按抗体的来源，可 将其分为天然抗体和免疫抗体。抗体就是免疫球蛋白，是改变了的球蛋白分子。由特异性抗原刺激产生，抗体的产生是由于抗原侵入人体后引起各种免疫细胞相互作用，使淋巴细胞中的B细胞分化增殖而形成浆细胞，浆细胞可产生分泌抗体。
ADMR上髓质素受体抗体规格:0.1ml
RUNX1T1/ETO周期素D相关蛋白抗体规格:0.1ml
PRB2/p130视网膜母细胞瘤相关蛋白p130抗体规格:0.1ml
Connexin-45间隙连接蛋白45抗体规格:0.1ml
CyclinD1/FSTL3周期素D1抗体规格:0.1ml
PRODH脯氨酸脱酶抗体规格:0.2ml
Deltex-1DTX1抗体规格:0.2ml
RabbitAnti-GoatIgM/PE-Cy5.5PE-Cy5.5标记的兔抗羊IgM规格:0.1ml
S100B/S100betaS100B蛋白抗体0.2ml
5-HTR2B5-羟色胺受体2B抗体0.1mlig Endothelin-1 (1-38), human Cys-Ser-Cys-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys-Val-Tyr- Phe-Cys-His-Leu-Asp-Ile-Ile-Trp-Val-Asn-Thr-Pro-Glu-His-Val-Val-Pro-Tyr-Gly-Leu-Gly-Ser-Pro-Arg-Ser(Disulfide bridge:Cys1-Cys15, Cys3-Cys11)
Biotin-β-Endomorphin, human Biotin-Tyr-Gly-Gly-Phe-Met-Thr-Ser-Glu-Lys-Ser-Gln-Thr-Pro-Leu-Val-Thr-Leu-Phe-Lys-Asn-Ala-Ile-Ile-Lys-Asn-Ala-Tyr-Lys-Lys-Gly-Glu
Caerulein (desulfated) Pyr-Gln-Asp-Tyr-Thr-Gly-Trp-Met-Asp-Phe-NH2
Cecropin A (1-8)-Melittin (1-18) amide Lys-Trp-Lys-Leu-Phe-Lys-Lys-Ile-Gly-Ile-Gly-Ala-Val-Leu-Lys-Val-Leu-Thr-Thr-Gly-Leu-Pro-Ala-Leu-Ile-Ser-NH2
Crustacean Cardioactive Peptide (CCAP) Pro-Phe-Cys-Asn-Ala-Phe-Thr-Gly-Cys
Dynorphin A (1-6), porcine Tyr-Gly-Gly-Phe-Leu-Arg
Exendin 4 His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-磷酸化细胞周期检控Rad17蛋白抗体说明书Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2
Gastric Inhibitory Polypeptide (6-30) amide (human) Phe-Ile-Ser-Asp-Tyr-Ser-Ile-Ala-Met-Asp-Lys-Ile-His-Gln-Gln-Asp-Phe-Val-Asn-Trp-Leu-Leu-Ala-Gln-Lys-NH2
gp100 (570-579) Ser-Leu-Ala-Asp-Thr-Asn-Ser-Leu-Ala-Val
HER2//neu(654-662) GP2 Ile-Ile-Ser-Ala-Val-Val-Gly-Ile-Leu
Hypercalcemia Malignancy Factor (7-34), amide, human Leu-Leu-His-Asp-Lys-Gly-Lys-Ser-Ile-Gln-Asp-Leu-Arg-Arg-Arg-Phe-Phe-Leu-His-His-Leu-Ile-Ala-Glu-Ile-His-Thr-Ala-NH2
K-G-D-S Lys-Gly-Asp-Ser
磷酸化细胞周期检控Rad17蛋白抗体说明书按理化性质和生物学功能，可将其分为IgM、IgG、IgA、IgE、IgD五类。
IgM抗体是免疫应答中首先分泌的抗体。它们在与抗原结合后启动补体的级联反应。它们还把入侵者相互连接起来，聚成一堆便于巨噬细胞的吞噬；
IgG抗体激活补体，中和多种毒素。IgG持续的时间长，是 唯一能在母亲妊娠期穿过胎盘保护胎儿的抗体。他们还从乳腺分泌进入初乳，使新生儿得 到保护；
IgA抗体进入身体的黏 膜表面，包括呼吸、消化、生殖等管道的黏膜，中和感染因子。还可以通过母乳的初乳把这种抗体输送到新生儿的消化道黏膜中，是在母乳中含量最多，最为重要的一类抗体；
IgE抗体的尾部与嗜碱细胞、肥大细胞的细胞膜结合。当抗体与抗原结合后，嗜碱细胞与肥大细胞释放组织胺一类物质促进炎症的发展。这也是引发速发型过敏反应的抗体；
IgD抗体的作用还不太清楚。它们主要出现在成熟的B淋巴细胞表面上，可能与B细胞的分化有关。（IgD于1995年从人骨髓瘤蛋白中发现，分子量为175kD，主要由扁桃体、脾等处浆细胞产生，人血清中IgD浓度为3～40μg/ml,不到血清总Ig的1%，在个体发育中合成较晚。IgD铰链区很长，且对蛋白酶水解敏感，因此IgD半衰期很短，仅2.8天。血清中IgD确切的免疫功能尚不清楚。在B细胞分化到成熟B细胞阶段，除了表达SmIgD，抗原刺激后表现为免疫耐受。成熟B细胞活化后或者活化后或者变成记忆B细胞时，SmIgD逐渐消失。
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文献和实验相关实验
进行全面审查。因此，本概述仅涉及当今蛋白质研究中研究的少数最常见类型的 PTM。此外，更多的重点放在磷酸化、糖基化和泛素化，因此这些 PTM 在各自的 PTM 专页中进行了更详细的描述。1、Phosphorylation：可逆的蛋白质磷酸化，主要发生在丝氨酸、苏氨酸或酪氨酸残基上，是目前研究得最深入的翻译后修饰之一。磷酸化在细胞周期、生长、凋亡和信号转导等过程中起着重要的调控作用。在以下示例中，使用蛋白免疫印迹分析评价分别用表皮生长因子 (EGF) 和血小板衍生生长因子 (PDGF) 刺激血清
祝贺〖雅裕睿安〗成为Signalway Antibody(SAB)独家
SAB(Signalway antibody ) 是一家汇聚了多名专家和学者的新型高科技生物公司，其研发和生产的抗体包括了数百种磷酸化 / 非磷酸化抗体 ( 可以提供同一位点的磷酸化 / 非磷酸化的成对抗体 ) ，为神经科学、细胞信号转导 (Akt pathway ， Jat/Sat pathway ， MAPK pathway ， NF-Kappa B pathway 等 ) 、癌症 / 凋亡、细胞周期、染色质 / 转录、细胞骨架通道、胰岛素 / 葡萄糖、核受体 / 膜受体
相关专题磷酸化评估蛋白激酶将磷酸基团从ATP转移到蛋白多肽底物上的丝氨酸、苏氨酸或酪氨酸残基，直接影响目标的活性和功能。放射性研究表明，真核细胞中大约30%的蛋白经过磷酸化修饰。这一关键的翻译后修饰调控了广泛的细胞活性，包括细胞周期 、分化、代谢和神经元通讯。此外，异常的磷酸化事件与许多疾病状态相关。在评估磷酸化时，选择的方法可能会有所不同，这取决于多个因素，包括提出的具体问题以及特殊仪器或试剂的可用性。如何检测蛋白磷酸化，本文简要介绍了几种常用方法，并提出了每种方法的优点和缺点
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磷酸化细胞周期检控Rad17蛋白抗体说明书
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