GTPase IMAP family member 5, Immunity-associated nucleotide 4-like 1 protein, Immunity-associated nucleotide 5 protein, IAN-5, hIAN5, Immunity-associated protein 3, GIMAP5, IAN4L1, IAN5, IMAP3, HIMAP3, IAN4, IROD.
INTRODUCTION
GTPase, IMAP Family Member 5 (GIMAP5) is a part of the GTP-binding superfamily and the immuno-associated nucleotide subfamily of nucleotide-binding proteins. GIMAP5 is an antiapoptotic protein which is required for mitochondrial integrity and T-cell survival. Polymorphisms in GIMAP5 are related with systemic lupus erythematosus. Read-through transcription can be found between GIMAP5 and the neighboring upstream GIMAP1 (GTPase, IMAP family member 1) gene. GIMAP5 also contributes to T-cell quiescence.
DESCRIPTION
GIMAP5 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 307 amino acids (1-284) and having a molecular mass of 34.4 kDa.
GIMAP5 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
SOURCE
Escherichia Coli.
PHYSICAL APPEARANCE
Sterile Filtered colorless solution.
FORMULATION
The GIMAP5 solution (0.25mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.2M NaCl, 40% glycerol and 2mM DTT.
STABILITY
Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Avoid multiple freeze-thaw cycles.
ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.