HTLV-1 p24 core

HTLV-1 p24 core

CATALOGUE NUMBER

HIV-108

INTRODUCTION

Human T-lymphotropic virus (HTLV) is a human, single-stranded RNA retrovirus that causes T-cell leukemia and T-cell lymphoma. The virus activates a subset of T-helper cellscalled Th1cells. The result is a proliferation of Th1 cells and overproduction of Th1 related cytokines (mainly IFN-gamma and TNF-alpha). Feedback mechanisms of these cytokines cause a suppression of the Th2 lymphocytes and a reduction of Th2 cytokine production (mainly IL-4, IL-5, IL-10 and IL-13). The end result is a reduction in the ability of the infected host to mount an adequate immune response to invading organisms that require a predominantly Th2 dependant response (these include parasitic infections and production of mucosal and humoral antibodies).

DESCRIPTION

The E.Coli derived recombinant protein contains the full-length sequence of HTLV-I p24, spanning all of p24.
The protein contains 214 amino acids having an Mw of 24kDa.

PURIFICATION METHOD

HTLV-1 p24 was purified by proprietary chromatographic technique.

PURITY

HTLV-1 p24 protein is >95% pure as determined by 10% PAGE (coomassie staining) and RP-HPLC.

FORMULATION

50mM NaPO4 pH 6.0, containing 1mM DTT & 1mM EDTA.

STABILITY

HTLV-1 p24 although stable at 4°C for 1 week, should be stored below -18°C. 
Please prevent freeze thaw cycles.

SPECIFICITY

Immunoreactive with all sera of HTLV-1 infected individuals.

APPLICATIONS

HTLV-1 p24 antigen can be used for ELISA and Western blots, excellent antigen for early detection of HIV seroconvertors with minimal specificity problems.

USAGE

ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.