产品概述:Location-regulated scaffold connecting MEK to RAF. Blocks MAP3K8 kinase activity and MAP3K8-mediated signaling. Acts as a negative regulator of MAP3K3-mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production.
靶点/蛋白:This KSR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 603-638 amino acids from the C-terminal region of human KSR2.
来源:Rabbit
存储溶液:Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
参考文献:Bailey, S.D., et al. Diabetes Care (2010) In press :Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Liu, L., et al. Biochim. Biophys. Acta 1794(10):1485-1495(2009)Zemunik, T., et al. Croat. Med. J. 50(1):23-33(2009)
特异性:Human
别名:Kinase suppressor of Ras 2, hKSR2, KSR2
应用:IHC-P~~1:50~100WB~~1:1000FC~~1:10~50
简单描述:Rabbit Polyclonal KSR2 Antibody (C-term). Validated for use in IHC-P, WB, FC, E.
详情:FunctionLocation-regulated scaffold connecting MEK to RAF. Has very low protein kinase activity and can phosphorylate MAP2K1 at several Ser and Thr residues with very low efficiency (in vitro). Interaction with BRAF enhances KSR2-mediated phosphorylation of MAP2K1 (in vitro). Blocks MAP3K8 kinase activity and MAP3K8- mediated signaling. Acts as a negative regulator of MAP3K3- mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production.Cellular_LocationCytoplasm. Membrane; Peripheral membrane proteinTissue_LocationMainly expressed in brain and kidney.