产品概述:NEPH1 is a member of the nephrin-like protein family,which includes NEPH2 (MIM 607761) and NEPH3 (MIM 607762). Thecytoplasmic domains of these proteins interact with the C terminusof podocin (NPHS2; MIM 604766), and the genes are expressed inkidney podocytes, cells involved in ensuring size- andcharge-selective ultrafiltration (Sellin et al., 2003 [PubMed12424224]).
靶点/蛋白:This KIRREL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 505-534 amino acids from the C-terminal region of human KIRREL.
来源:Rabbit
存储溶液:Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
参考文献:Machuca, E., et al. J. Am. Soc. Nephrol. 21(7):1209-1217(2010)Wagner, M.C., et al. J. Biol. Chem. 283(51):35579-35589(2008)Hartleben, B., et al. J. Biol. Chem. 283(34):23033-23038(2008)Harita, Y., et al. J. Biol. Chem. 283(14):9177-9186(2008)Ihalmo, P., et al. Diabetologia 51(1):86-90(2008)
特异性:Human
别名:Kin of IRRE-like protein 1, Kin of irregular chiasm-like protein 1, Nephrin-like protein 1, KIRREL, KIRREL1, NEPH1
应用:WB~~1:1000
简单描述:Rabbit Polyclonal KIRREL Antibody(C-term). Validated for use in WB, E.
详情:FunctionPlays a significant role in the normal development and function of the glomerular permeability. Signaling protein that needs the presence of TEC kinases to fully trans-activate the transcription factor AP-1 (By similarity).Cellular_LocationCell membrane; Single-pass type I membrane protein. Note=Predominantly located at podocyte slit diaphragmTissue_LocationAbundantly expressed in kidney. Specifically expressed in podocytes of kidney glomeruli