产品概述:This gene encodes one of four mammalian counterparts to the fruit fly 'dunce' gene. The encoded protein has 3',5'-cyclic-AMP phosphodiesterase activity and degrades cAMP, which acts as a signal transduction molecule in multiple cell types. This gene uses different promoters to generate multiple alternatively spliced transcript variants that encode functional proteins.
来源:Goat
存储溶液:0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin
参考文献:Analyses of shared genetic factors between asthma and obesity in children. Mel茅n E, et al. J Allergy Clin Immunol, 2010 Sep. PMID 20816195.[Phosphodiesterase 4D (PDE4D) gene polymorphism in patients with acute stroke from Moscow] . Genetika, 2010 Jun. PMID 20734779.A genome-wide association study of neuroticism in a population-based sample. Calboli FC, et al. PLoS One, 2010 Jul 9. PMID 20634892.Variation at the NFATC2 Locus Increases the Risk of Thiazolinedinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study. Bailey SD, et al. Diabetes Care, 2010 Jul 13. PMID 20628086.Sex-differential genetic effect of phosphodiesterase 4D (PDE4D) on carotid atherosclerosis. Liao YC, et al. BMC Med Genet, 2010 Jun 12. PMID 20540798.
简单描述:Goat Polyclonal Goat Anti-PDE4D3 Antibody. Validated for use in WB, E.
详情:FunctionHydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.Cellular_LocationApical cell membrane. Cytoplasm. Membrane. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Found in the soluble fraction, associated with membranes, and associated with the cytoskeleton and the centrosome (By similarity). Colocalized with SHANK2 to the apical membrane of colonic crypt cells.Tissue_LocationExpressed in colonic epithelial cells (at protein level). Widespread; most abundant in skeletal muscle Isoform 6 is detected in brain. Isoform 8 is detected in brain, placenta, lung and kidney. Isoform 7 is detected in heart and skeletal muscle.