产品概述:This gene encodes a protein that is involved in lysosomalfunction. Mutations in this, as well as other neuronalceroid-lipofuscinosis (CLN) genes, cause neurodegenerative diseasescommonly known as Batten disease or collectively known as neuronalceroid lipofuscinoses (NCLs). Many alternatively spliced transcriptvariants have been found for this gene.
靶点/蛋白:This CLN3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 235-263 amino acids from the Central region of human CLN3.
来源:Rabbit
存储溶液:Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
参考文献:Adams, H.R., et al. Dev Med Child Neurol 52(7):637-643(2010)Imielinski, M., et al. Nat. Genet. 41(12):1335-1340(2009)Sarpong, A., et al. Clin. Genet. 76(1):38-45(2009)Codlin, S., et al. J. Cell. Sci. 122 (PT 8), 1163-1173 (2009) :Tuxworth, R.I., et al. Hum. Mol. Genet. 18(4):667-678(2009)
特异性:Human
别名:Battenin, Batten disease protein, Protein CLN3, CLN3, BTS
应用:WB~~1:1000
简单描述:Rabbit Polyclonal CLN3 Antibody (Center). Validated for use in WB, E.
详情:FunctionInvolved in microtubule-dependent, anterograde transport of late endosomes and lysosomes.Cellular_LocationLysosome membrane; Multi- pass membrane protein. Late endosome