产品概述:CDH10 is a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. The extracellular domain consists of 5 subdomains, each containing a cadherin motif, and appears to determine the specificity of the protein's homophilic cell adhesion activity. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. This particular cadherin is predominantly expressed in brain and is putatively involved in synaptic adhesions, axon outgrowth and guidance.
靶点/蛋白:This CDH10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 25-55 amino acids from the N-terminal region of human CDH10.
来源:Rabbit
存储溶液:Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
参考文献:Kools,P., FEBS Lett. 452 (3), 328-334 (1999)
特异性:Human
别名:Cadherin-10, T2-cadherin, CDH10
应用:WB~~1:1000IHC-P~~1:10~50FC~~1:10~50
简单描述:Rabbit Polyclonal CDH10 Antibody (N-term). Validated for use in WB, IHC-P, FC, E.
详情:FunctionCadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.Cellular_LocationCell membrane; Single-pass type I membrane proteinTissue_LocationPredominantly expressed in brain. Also found in adult and fetal kidney. Very low levels detected in prostate and fetal lung.